Western Blot (WB)
(SOCS6 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SOCS6 antibody detected the SOCS6 protein (arrow).)
Rabbit anti-Human SOCS6 Polyclonal Antibody | anti-SOCS6 antibody
SOCS6 Antibody (N-term)
Western Blot (WB)
(SOCS6 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SOCS6 antibody detected the SOCS6 protein (arrow).)
Western Blot (WB)
(SOCS6 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SOCS6 antibody detected the SOCS6 protein (arrow).)
Immunohistochemistry (IHC)
(SOCS6 Antibody (N-term) (MBS9205358)immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SOCS6 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(SOCS6 Antibody (N-term) (MBS9205358)immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SOCS6 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
a CIS homolog domain. The protein thus belongs to the
cytokine-induced STAT inhibitor (CIS), also known as suppressor of
cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI),
protein family. CIS family members are known to be
cytokine-inducible negative regulators of cytokine signaling. The
expression of this gene can be induced by GM-CSF and EPO in
hematopoietic cells. A high expression level of this gene was found
in factor-independent chronic myelogenous leukemia (CML) and
erythroleukemia (HEL) cell lines.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Choi, Y.B., et al. J. Biol. Chem. 285(10):7271-7280(2010)
Lai, R.H., et al. Gene 448(1):64-73(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]
Uniprot Description
SOCS6: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 18q22.2
Cellular Component: cytoplasm; immunological synapse
Molecular Function: protein binding; protein kinase inhibitor activity
Biological Process: proteasomal protein catabolic process; cytokine and chemokine mediated signaling pathway; regulation of growth; protein ubiquitination; negative regulation of protein kinase activity; defense response; JAK-STAT cascade; negative regulation of T cell activation; negative regulation of JAK-STAT cascade
Research Articles on SOCS6
Similar Products
Product Notes
The SOCS6 socs6 (Catalog #AAA9205358) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 40-69. The SOCS6 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SOCS6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the SOCS6 socs6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SOCS6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
