MALT1 sirna

MALT1 siRNA (Mouse)

Cat. Num. AAA8201354

• Gene Names: Malt1; A630046N12; D430033E09Rik
• Reactivity: Mouse
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: MALT1; MALT1 siRNA (Mouse); Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog; Paracaspase; MALT1 sirna

• Host: Synthetic
• Reactivity: Mouse
• Specificity: MALT1 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 821

• Applicable Applications for MALT1 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse MALT1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for MALT1 sirna

siRNA to inhibit MALT1 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 27370250
• NCBI GeneID: 240354
• NCBI Accession #: NP_766421.1
• NCBI GenBank Nucleotide #: NM_172833.2
• UniProt Accession #: Q2TBA3; Q2TBA2; Q811E3; Q8BFT0; Q8C7N9
• Molecular Weight: 32,428 Da
• NCBI Official Full Name: mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog
• NCBI Official Synonym Full Names: MALT1 paracaspase
• NCBI Official Symbol: Malt1
• NCBI Official Synonym Symbols: A630046N12; D430033E09Rik
• NCBI Protein Information: mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog
• UniProt Protein Name: Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog
• Protein Family: Mucosa-associated lymphoid tissue lymphoma translocation protein
• UniProt Gene Name: Malt1
• UniProt Entry Name: MALT1_MOUSE

Uniprot Description

MALT1: Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6. Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. Belongs to the peptidase C14B family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear export; Ligase; Apoptosis; Protease; Adaptor/scaffold; EC 3.4.22.-; Ubiquitin conjugating system

Cellular Component: protein complex; cytoplasm; nucleolus; intracellular; nucleus; cytosol

Molecular Function: peptidase activity; protein binding; signal transducer activity; protease binding; protein self-association; hydrolase activity; cysteine-type endopeptidase activity; ubiquitin-protein ligase activity; kinase activator activity

Biological Process: response to fungus; I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; B cell activation; apoptosis; nuclear export; activation of NF-kappaB-inducing kinase; positive regulation of T cell cytokine production; protein ubiquitination; proteolysis; T cell receptor signaling pathway; protein oligomerization; activation of NF-kappaB transcription factor; regulation of apoptosis; T cell proliferation; B-1 B cell differentiation; regulation of T cell receptor signaling pathway; positive regulation of interleukin-2 production; positive regulation of T cell activation