CREB3L4 sirna

CREB3L4 siRNA (Mouse)

Cat. Num. AAA8207864

• Gene Names: Creb3l4; JAL; CREB4; acre1; AIBZIP; TISP40; AV040530; AV258827; 1700012K17Rik; 5330432F22Rik
• Reactivity: Mouse
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: CREB3L4; CREB3L4 siRNA (Mouse); ATCE1; JAL; TISP40; Cyclic AMP-responsive element-binding protein 3-like protein 4; cAMP-responsive element-binding protein 3-like protein 4; Attaching to CRE-like 1; Acre1; Transcript induced in spermiogenesis protein 40; Tisp40; mJAL; CREB3L4 sirna

• Host: Synthetic
• Reactivity: Mouse
• Specificity: CREB3L4 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 315

• Applicable Applications for CREB3L4 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse CREB3L4 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for CREB3L4 sirna

siRNA to inhibit CREB3L4 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 808154271
• NCBI GeneID: 78284
• NCBI Accession #: NP_001294863.1
• NCBI GenBank Nucleotide #: NM_001307934.1
• UniProt Accession #: Q9D2A5; Q9DAE0
• Molecular Weight: 35,020 Da
• NCBI Official Full Name: cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1
• NCBI Official Synonym Full Names: cAMP responsive element binding protein 3-like 4
• NCBI Official Symbol: Creb3l4
• NCBI Official Synonym Symbols: JAL; CREB4; acre1; AIBZIP; TISP40; AV040530; AV258827; 1700012K17Rik; 5330432F22Rik
• NCBI Protein Information: cyclic AMP-responsive element-binding protein 3-like protein 4
• UniProt Protein Name: Cyclic AMP-responsive element-binding protein 3-like protein 4
• Protein Family: Cyclic AMP-responsive element-binding protein 3-like protein
• UniProt Gene Name: Creb3l4
• UniProt Synonym Gene Names: Atce1; Jal; Tisp40; cAMP-responsive element-binding protein 3-like protein 4; ATCE1; Acre1; Tisp40
• UniProt Entry Name: CR3L4_MOUSE

NCBI Description

This gene encodes a CREB (cyclic AMP-responsive element-binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein may play a role in adiposity and male germ cell development. Homozygous knockout mice for this gene show increased adipogenesis, elevated testicular germ cell apoptosis and defects in spermatogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Uniprot Description

CREB3L4: Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements. Belongs to the bZIP family. ATF subfamily.

Protein type: Membrane protein, integral; Transcription factor; Endoplasmic reticulum

Cellular Component: Golgi apparatus; membrane; endoplasmic reticulum; integral to membrane; cytoplasmic vesicle; nucleus

Molecular Function: DNA binding; sequence-specific DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; transcription, DNA-dependent; regulation of transcription, DNA-dependent; unfolded protein response; multicellular organismal development; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; cell differentiation; response to unfolded protein