ACVR1 sirna

ACVR1 siRNA (Mouse)

Cat. Num. AAA8208759

• Gene Names: Acvr1; ALK2; Acvr; Alk8; SKR1; Alk-2; Tsk7L; ActR-I; ActRIA; Acvrlk2; D330013D15Rik
• Reactivity: Mouse
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: ACVR1; ACVR1 siRNA (Mouse); ACVRLK2; TGFB1; Activin receptor type-1; Activin receptor type I; ACTR-I; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I; TSK-7L; ACVR1 sirna

• Host: Synthetic
• Reactivity: Mouse
• Specificity: ACVR1 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 509

• Applicable Applications for ACVR1 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse ACVR1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for ACVR1 sirna

siRNA to inhibit ACVR1 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 158937274
• NCBI GeneID: 11477
• NCBI Accession #: NP_001103674.1
• NCBI GenBank Nucleotide #: NM_001110204.1
• UniProt Accession #: P37172; Q3UDH5; Q91VF1
• Molecular Weight: 57,226 Da
• NCBI Official Full Name: activin receptor type-1
• NCBI Official Synonym Full Names: activin A receptor, type 1
• NCBI Official Symbol: Acvr1
• NCBI Official Synonym Symbols: ALK2; Acvr; Alk8; SKR1; Alk-2; Tsk7L; ActR-I; ActRIA; Acvrlk2; D330013D15Rik
• NCBI Protein Information: activin receptor type-1
• UniProt Protein Name: Activin receptor type-1
• Protein Family: Activin receptor
• UniProt Gene Name: Acvr1
• UniProt Synonym Gene Names: Acvrlk2; Tgfb1; ACTR-I; SKR1; TSR-I
• UniProt Entry Name: ACVR1_MOUSE

Uniprot Description

ALK2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis. Interacts with FKBP1A. Interacts with FCHO1. Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Protein type: Protein kinase, Ser/Thr (receptor); Kinase, protein; Protein kinase, TKL; EC 2.7.11.30; Membrane protein, integral; TKL group; STKR family; Type1 subfamily

Cellular Component: membrane; integral to plasma membrane; apical part of cell; integral to membrane; activin receptor complex

Molecular Function: protein homodimerization activity; metal ion binding; nucleotide binding; transmembrane receptor protein serine/threonine kinase activity; protein kinase activity; transferase activity; protein serine/threonine kinase activity; activin receptor activity, type I; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; growth factor binding; transferase activity, transferring phosphorus-containing groups; activin binding; kinase activity; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: heart development; positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; gastrulation; protein amino acid phosphorylation; germ cell development; BMP signaling pathway; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein serine/threonine kinase signaling pathway; mesoderm development; neural crest cell migration; pharyngeal system development; in utero embryonic development; peptidyl-threonine phosphorylation; gastrulation with mouth forming second; positive regulation of bone mineralization; negative regulation of signal transduction; patterning of blood vessels; positive regulation of osteoblast differentiation; negative regulation of activin receptor signaling pathway; embryonic development; mesoderm formation; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; regulation of ossification; determination of left/right symmetry; phosphorylation; urogenital system development; G1/S transition of mitotic cell cycle