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TRPM3 sirna

TRPM3 siRNA (Human)

Gene Names
TRPM3; GON-2; MLSN2; LTRPC3
Reactivity
Human
Applications
RNA Interference (RNAi)
Purity
> 97%
Synonyms
TRPM3; TRPM3 siRNA (Human); KIAA1616; LTRPC3; Transient receptor potential cation channel subfamily M member 3; Long transient receptor potential channel 3; LTrpC-3; LTrpC3; Melastatin-2; MLSN2; TRPM3 sirna
Ordering
 
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For Research Use Only!
Host
Synthetic
Reactivity
Human
Specificity
TRPM3 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
Purity/Purification
> 97%
Form/Format
Lyophilized powder
Sequence Length
230
Applicable Applications for TRPM3 sirna
RNA Interference (RNAi)
Quality Control
Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
Directions for Use
We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
Components
We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human TRPM3 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Related Product Information for TRPM3 sirna
siRNA to inhibit TRPM3 expression using RNA interference

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
25,159 Da
NCBI Official Full Name
transient receptor potential cation channel subfamily M member 3 isoform k
NCBI Official Synonym Full Names
transient receptor potential cation channel, subfamily M, member 3
NCBI Official Symbol
TRPM3
NCBI Official Synonym Symbols
GON-2; MLSN2; LTRPC3
NCBI Protein Information
transient receptor potential cation channel subfamily M member 3
UniProt Protein Name
Transient receptor potential cation channel subfamily M member 3
UniProt Gene Name
TRPM3
UniProt Synonym Gene Names
KIAA1616; LTRPC3; LTrpC-3; LTrpC3; MLSN2
UniProt Entry Name
TRPM3_HUMAN

NCBI Description

The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

TRPM3: a transient receptor potential (TRP) ion channel. Mediates constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by calcium store depletion and muscarinic receptor activation. TRP voltage-independent calcium-permeable cation channels are divided into six subfamilies, two of which (TRPC and TRPM) have members that are widely expressed. Ten alternatively spliced isoforms have been described.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, cation

Chromosomal Location of Human Ortholog: 9q21.12

Cellular Component: integral to membrane; plasma membrane

Molecular Function: calcium channel activity; cation channel activity; calcium activated cation channel activity

Biological Process: detection of temperature stimulus; sensory perception of temperature stimulus; transmembrane transport; cation transport

Research Articles on TRPM3

Similar Products

Product Notes

The TRPM3 trpm3 (Catalog #AAA8207908) is a siRNA produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. The TRPM3 siRNA (Human) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TRPM3 can be used in a range of immunoassay formats including, but not limited to, RNA Interference (RNAi). Researchers should empirically determine the suitability of the TRPM3 trpm3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRPM3, siRNA" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.
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