SLC6A14 sirna

SLC6A14 siRNA (Human)

Cat. Num. AAA8223760

• Gene Names: SLC6A14; BMIQ11
• Reactivity: Human
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: SLC6A14; SLC6A14 siRNA (Human); Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+; Amino acid transporter ATB0+; Solute carrier family 6 member 14; SLC6A14 sirna

• Host: Synthetic
• Reactivity: Human
• Specificity: SLC6A14 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 642

• Applicable Applications for SLC6A14 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human SLC6A14 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for SLC6A14 sirna

siRNA to inhibit SLC6A14 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 6005715
• NCBI GeneID: 11254
• NCBI Accession #: NP_009162.1
• NCBI GenBank Nucleotide #: NM_007231.4
• UniProt Accession #: Q9UN76; Q5H942
• Molecular Weight: 72,153 Da
• NCBI Official Full Name: sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
• NCBI Official Synonym Full Names: solute carrier family 6 (amino acid transporter), member 14
• NCBI Official Symbol: SLC6A14
• NCBI Official Synonym Symbols: BMIQ11
• NCBI Protein Information: sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
• UniProt Protein Name: Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
• Protein Family: Sodium- and chloride-dependent neutral and basic amino acid transporter
• UniProt Gene Name: SLC6A14
• UniProt Entry Name: S6A14_HUMAN

NCBI Description

This gene encodes a member of the solute carrier family 6. Members of this family are sodium and chloride dependent neurotransmitter transporters. The encoded protein transports both neutral and cationic amino acids. This protein may also function as a beta-alanine carrier. Mutations in this gene may be associated with X-linked obesity. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, May 2010]

Uniprot Description

SLC6A14: Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner. Genetic variations in SLC6A14 may be associated with obesity in some populations, as shown by significant differences in allele frequencies between obese and non-obese individuals. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A14 subfamily.

Protein type: Transporter; Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq23

Cellular Component: brush border membrane; plasma membrane; integral to membrane; vesicle

Molecular Function: neurotransmitter:sodium symporter activity; amino acid transmembrane transporter activity

Biological Process: amino acid metabolic process; neurotransmitter transport; amino acid transport; transport; response to toxin; ion transport; transmembrane transport

Disease: Body Mass Index Quantitative Trait Locus 11