SLC26A2 sirna

SLC26A2 siRNA (Human)

Cat. Num. AAA8221346

• Gene Names: SLC26A2; DTD; EDM4; DTDST; MST153; D5S1708; MSTP157
• Reactivity: Human
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: SLC26A2; SLC26A2 siRNA (Human); DTD; DTDST; Sulfate transporter; Diastrophic dysplasia protein; Solute carrier family 26 member 2; SLC26A2 sirna

• Host: Synthetic
• Reactivity: Human
• Specificity: SLC26A2 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 739

• Applicable Applications for SLC26A2 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human SLC26A2 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for SLC26A2 sirna

siRNA to inhibit SLC26A2 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 100913030
• NCBI GeneID: 1836
• NCBI Accession #: NP_000103.2
• NCBI GenBank Nucleotide #: NM_000112.3
• UniProt Accession #: P50443; Q6N051; A8K2U3; B2R6J1
• Molecular Weight: 81,662 Da
• NCBI Official Full Name: sulfate transporter
• NCBI Official Synonym Full Names: solute carrier family 26 (anion exchanger), member 2
• NCBI Official Symbol: SLC26A2
• NCBI Official Synonym Symbols: DTD; EDM4; DTDST; MST153; D5S1708; MSTP157
• NCBI Protein Information: sulfate transporter
• UniProt Protein Name: Sulfate transporter
• Protein Family: Sulfate transporter
• UniProt Gene Name: SLC26A2
• UniProt Synonym Gene Names: DTD; DTDST
• UniProt Entry Name: S26A2_HUMAN

NCBI Description

The diastrophic dysplasia sulfate transporter is a transmembrane glycoprotein implicated in the pathogenesis of several human chondrodysplasias. It apparently is critical in cartilage for sulfation of proteoglycans and matrix organization. [provided by RefSeq, Jul 2008]

Uniprot Description

SLC26A2: Sulfate transporter. May play a role in endochondral bone formation. Defects in SLC26A2 are the cause of diastrophic dysplasia (DTD). DTD is an autosomal recessive disease characterized by osteochondrodysplasia with clinical features including dwarfism, spinal deformation, and specific joint abnormalities. Defects in SLC26A2 are the cause of achondrogenesis type 1B (ACG1B). ACG1B is a recessively inherited chondrodysplasia characterized by extremely poor skeletal development and perinatal death. Defects in SLC26A2 are the cause of atelosteogenesis type 2 (AO2); also known as neonatal osseous dysplasia 1. AO2 is characterized by severely shortened limbs, small chest, scoliosis, club foot of the equinovarus type (talipes equinovarus), abducted thumbs and great toes, and cleft palate. Patients die of respiratory insufficiency shortly after birth because of the collapse of the airways and pulmonary hypoplasia due to the small rib cage. Defects in SLC26A2 are the cause of multiple epiphyseal dysplasia type 4 (EDM4). EDM is a generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. EDM is broadly categorized into the more severe Fairbank and the milder Ribbing types. EDM4 is a recessively inherited form, characterized by early childhood-onset hip dysplasia and recurrent patella dislocation. Short stature in EDM4 patients is not frequent. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.

Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, SLC family

Chromosomal Location of Human Ortholog: 5q31-q34

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: sulfate transmembrane transporter activity; secondary active sulfate transmembrane transporter activity

Biological Process: ossification; glycosaminoglycan metabolic process; xenobiotic metabolic process; carbohydrate metabolic process; sulfate transport; ion transport; pathogenesis; transmembrane transport; 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process; 3'-phosphoadenosine 5'-phosphosulfate metabolic process

Disease: Atelosteogenesis, Type Ii; Diastrophic Dysplasia; Achondrogenesis, Type Ib; Epiphyseal Dysplasia, Multiple, 4