NCBI Description
This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]
Uniprot Description
DLC1: Functions as a GTPase-activating protein specific for Rho and an activator of PLCD1 in vivo and induces morphological changes and detachment through cytoskeletal reorganization. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs; GAPs, Rac/Rho; Tumor suppressor
Chromosomal Location of Human Ortholog: 8p22
Cellular Component: cortical actin cytoskeleton; focal adhesion; cytoplasm; caveola; nucleus; cytosol
Molecular Function: protein binding; SH2 domain binding; lipid binding
Biological Process: caspase activation; heart morphogenesis; focal adhesion formation; hindbrain morphogenesis; negative regulation of stress fiber formation; apoptosis; negative regulation of focal adhesion formation; positive regulation of protein amino acid dephosphorylation; negative regulation of cell proliferation; regulation of cell shape; regulation of small GTPase mediated signal transduction; negative regulation of Rho protein signal transduction; small GTPase mediated signal transduction; regulation of actin cytoskeleton organization and biogenesis; forebrain development; neural tube closure; actin cytoskeleton organization and biogenesis; negative regulation of cell migration
Disease: Colorectal Cancer
Product Notes
The DLC1 dlc1 (Catalog #
AAA8236944) is a siRNA produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. The DLC1 siRNA (Human) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DLC1 can be used in a range of immunoassay formats including, but not limited to, RNA Interference (RNAi). Researchers should empirically determine the suitability of the DLC1 dlc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"DLC1, siRNA" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech
cannot be held
responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
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of any product performance
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