MNT blocking peptide

MNT Blocking Peptide

Cat. Num. AAA822363

• Gene Names: MNT; ROX; MAD6; MXD6; bHLHd3
• Reactivity: Human, Mouse, Rat
• Applications: Blocking (BL)
• Purity: >85%
• Synonyms: MNT; MNT Blocking Peptide; BHLHD3; ROX; Max-binding protein MNT; Class D basic helix-loop-helix protein 3; bHLHd3; Myc antagonist MNT; Protein ROX; MNT blocking peptide

• Host: Synthetic
• Reactivity: Human, Mouse, Rat
• Purity/Purification: >85%
• Form/Format: Lyophilized powder
• Sequence Length: 582

• Applicable Applications for MNT blocking peptide: Blocking (BL)
• Application Notes: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
• Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for MNT blocking peptide

The peptide is used to block Anti-MNT Antibody reactivity.

NCBI and Uniprot Product Information

• NCBI GI #: 9945318
• NCBI GeneID: 4335
• NCBI Accession #: NP_064706.1
• NCBI GenBank Nucleotide #: NM_020310.2
• UniProt Accession #: Q99583; Q1ED38; A8K6D1; D3DTI7
• Molecular Weight: 62,300 Da
• NCBI Official Full Name: max-binding protein MNT
• NCBI Official Synonym Full Names: MAX network transcriptional repressor
• NCBI Official Symbol: MNT
• NCBI Official Synonym Symbols: ROX; MAD6; MXD6; bHLHd3
• NCBI Protein Information: max-binding protein MNT; myc antagonist MNT; MAX binding protein; Max-interacting protein; MNT, MAX dimerization protein; class D basic helix-loop-helix protein 3
• UniProt Protein Name: Max-binding protein MNT
• Protein Family: Max-binding protein
• UniProt Gene Name: MNT
• UniProt Synonym Gene Names: BHLHD3; ROX; bHLHd3
• UniProt Entry Name: MNT_HUMAN

NCBI Description

The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]

Uniprot Description

MNT: Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein dimerization activity; transcription coactivator activity; chromatin binding; transcription corepressor activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; negative regulation of cell proliferation; regulation of cell cycle; multicellular organismal development; cell aging; negative regulation of transcription from RNA polymerase II promoter