Rabbit MNT Polyclonal Antibody | anti-MNT antibody

Anti-MNT Antibody

Cat. Num. AAA822012

• Gene Names: MNT; ROX; MAD6; MXD6; bHLHd3
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was purified by immunogen affinity chromatography.
• Synonyms: MNT; Polyclonal Antibody; Anti-MNT Antibody; BHLHD3; ROX; Max-binding protein MNT; Class D basic helix-loop-helix protein 3; bHLHd3; Myc antagonist MNT; Protein ROX; anti-MNT antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of MNT protein.
• Purity/Purification: The antibody was purified by immunogen affinity chromatography.
• Form/Format: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
• Sequence Length: 582

• Applicable Applications for anti-MNT antibody: Western Blot (WB)
• Application Notes: WB (1/500 - 1/1000)
• Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MNT. The exact sequence is proprietary.
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of MNT expression in Jurkat (A), HeLa (B) whole cell lysates.)

Related Product Information for anti-MNT antibody

Rabbit polyclonal antibody to MNT

NCBI and Uniprot Product Information

• NCBI GI #: 9945318
• NCBI GeneID: 4335
• NCBI Accession #: NP_064706.1
• NCBI GenBank Nucleotide #: NM_020310.2
• UniProt Accession #: Q99583; Q1ED38; A8K6D1; D3DTI7
• Molecular Weight: 62,300 Da
• NCBI Official Full Name: max-binding protein MNT
• NCBI Official Synonym Full Names: MAX network transcriptional repressor
• NCBI Official Symbol: MNT
• NCBI Official Synonym Symbols: ROX; MAD6; MXD6; bHLHd3
• NCBI Protein Information: max-binding protein MNT; myc antagonist MNT; MAX binding protein; Max-interacting protein; MNT, MAX dimerization protein; class D basic helix-loop-helix protein 3
• UniProt Protein Name: Max-binding protein MNT
• Protein Family: Max-binding protein
• UniProt Gene Name: MNT
• UniProt Synonym Gene Names: BHLHD3; ROX; bHLHd3
• UniProt Entry Name: MNT_HUMAN

NCBI Description

The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]

Uniprot Description

MNT: Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein dimerization activity; transcription coactivator activity; chromatin binding; transcription factor activity; transcription corepressor activity

Biological Process: transcription from RNA polymerase II promoter; negative regulation of cell proliferation; regulation of cell cycle; multicellular organismal development; cell aging; negative regulation of transcription from RNA polymerase II promoter