OCRL blocking peptide
OCRL Blocking Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a phosphatase enzyme that is involved in actin polymerization and is found in the trans-Golgi network. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. [provided by RefSeq, Jul 2008]
Uniprot Description
OCRL: Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5- tetrakisphosphate to inositol 1,3,4-trisphosphate. May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Belongs to the inositol-1,4,5-trisphosphate 5- phosphatase type II family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.3.36; Phosphatase (non-protein); Carbohydrate Metabolism - inositol phosphate; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: Xq25
Cellular Component: Golgi stack; clathrin-coated vesicle; early endosome; coated pit; trans-Golgi network; cytosol; phagocytic vesicle membrane; photoreceptor outer segment; early endosome membrane; cytoplasm; plasma membrane; Golgi-associated vesicle; nucleus
Molecular Function: protein binding; phosphoinositide 5-phosphatase activity; Rac GTPase binding
Biological Process: regulation of small GTPase mediated signal transduction; inositol phosphate metabolic process; in utero embryonic development; phospholipid metabolic process; small GTPase mediated signal transduction; phosphatidylinositol biosynthetic process; cilium biogenesis; phosphoinositide dephosphorylation; lipid metabolic process
Disease: Lowe Oculocerebrorenal Syndrome; Dent Disease 2
Research Articles on OCRL
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Product Notes
The OCRL ocrl (Catalog #AAA823291) is a Blocking Peptide produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. The OCRL Blocking Peptide reacts with Human, Monkey and may cross-react with other species as described in the data sheet. AAA Biotech's OCRL can be used in a range of immunoassay formats including, but not limited to, Blocking (BL). Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours. Researchers should empirically determine the suitability of the OCRL ocrl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "OCRL, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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