USP44 blocking peptide
USP44 Blocking Peptide
NCBI and Uniprot Product Information
NCBI Description
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP44 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]
Uniprot Description
USP44: Deubiquitinase that plays a key role in the spindle checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20- APC/C ternary complex (also named mitotic checkpoint), thereby preventing premature activation of the APC/C. Belongs to the peptidase C19 family. USP44 subfamily.
Protein type: Protease; EC 3.4.19.12; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 12q22
Cellular Component: microtubule cytoskeleton; nucleolus; nucleus
Molecular Function: protein binding; ubiquitin-specific protease activity; zinc ion binding
Biological Process: cell division; mitosis; proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination
Research Articles on USP44
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Product Notes
The USP44 usp44 (Catalog #AAA8244225) is a Blocking Peptide produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. The USP44 Blocking Peptide reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's USP44 can be used in a range of immunoassay formats including, but not limited to, Blocking (BL). Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours. Researchers should empirically determine the suitability of the USP44 usp44 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "USP44, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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