Hairless Blocking Peptide | HR blocking peptide

Hairless Blocking Peptide

Cat. Num. AAA8309555

• Gene Names: HR; AU; MUHH; ALUNC; MUHH1; HSA277165
• Reactivity: Human, Rat
• Applications: Blocking (BL)
• Purity: >85%
• Synonyms: Hairless; Hairless Blocking Peptide; Protein hairless; HR blocking peptide

• Host: Synthetic
• Reactivity: Human, Rat
• Purity/Purification: >85%
• Form/Format: Lyophilized Powder

• Applicable Applications for HR blocking peptide: Blocking (BL)
• Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
• Directions for Use: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
• Preparation and Storage: Store at -20 degree C for one year.

Related Product Information for HR blocking peptide

The peptide is used to block Anti-Hairless Antibody reactivity.

NCBI and Uniprot Product Information

• NCBI GI #: 22547204
• NCBI GeneID: 55806
• NCBI Accession #: NP_005135.2
• NCBI GenBank Nucleotide #: NM_005144.4
• UniProt Accession #: O43593; P97609
• Molecular Weight: 127,495 Da
• NCBI Official Full Name: protein hairless isoform a
• NCBI Official Synonym Full Names: hair growth associated
• NCBI Official Symbol: HR
• NCBI Official Synonym Symbols: AU; MUHH; ALUNC; MUHH1; HSA277165
• NCBI Protein Information: protein hairless; hairless homolog
• UniProt Protein Name: Protein hairless
• UniProt Gene Name: HR
• UniProt Entry Name: HAIR_HUMAN

NCBI Description

This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by multiple regulatory ORFs that exist upstream of the primary ORF. Mutations in one of these upstream ORFs, U2HR, cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Uniprot Description

HR: May act as a transcription factor that could act on to regulate one of the phases of hair growth. Defects in HR are the cause of alopecia universalis congenita (ALUNC). ALUNC is a rare autosomal recessive form of hair loss characterized by hair follicles without hair. Defects in HR are the cause of atrichia with papular lesions (APL); also known as congenital atrichia. APL is an autosomal recessive disease characterized by papillary lesions over most of the body and almost complete absence of hair. Defects in HR are the cause of hypotrichosis type 4 (HYPT4). An autosomal dominant condition characterized by reduced amount of hair, alopecia, little or no eyebrows, eyelashes or body hair, and coarse, wiry, twisted hair in early childhood. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 8p21.2

Cellular Component: nuclear body; nucleus

Molecular Function: DNA binding; metal ion binding; oxidoreductase activity; transcription factor activity; transcription corepressor activity

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; negative regulation of transcription, DNA-dependent

Disease: Hypotrichosis 4; Alopecia Universalis Congenita; Atrichia With Papular Lesions