TAF5L blocking peptide

TAF5L Blocking Peptide

Cat. Num. AAA8243507

• Gene Names: TAF5L; PAF65B
• Reactivity: Human, Dog, Monkey, Rabbit
• Applications: Blocking (BL)
• Purity: >85%
• Synonyms: TAF5L; TAF5L Blocking Peptide; PAF65B; TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L; PCAF-associated factor 65 beta; PAF65-beta; TAF5L blocking peptide

• Host: Synthetic
• Reactivity: Human, Dog, Monkey, Rabbit
• Purity/Purification: >85%
• Form/Format: Lyophilized Powder
• Sequence Length: 589

• Applicable Applications for TAF5L blocking peptide: Blocking (BL)
• Application Notes: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
• Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for TAF5L blocking peptide

The peptide is used to block Anti-TAF5L Antibody reactivity.

NCBI and Uniprot Product Information

• NCBI GI #: 46577305
• NCBI GeneID: 27097
• UniProt Accession #: O75529; Q5TDI5; Q5TDI6; Q8IW31
• Molecular Weight: 36,991 Da
• NCBI Official Full Name: TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
• NCBI Official Synonym Full Names: TATA-box binding protein associated factor 5 like
• NCBI Official Symbol: TAF5L
• NCBI Official Synonym Symbols: PAF65B
• NCBI Protein Information: TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
• UniProt Protein Name: TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
• Protein Family: TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor
• UniProt Gene Name: TAF5L
• UniProt Synonym Gene Names: PAF65B; PAF65-beta
• UniProt Entry Name: TAF5L_HUMAN

NCBI Description

The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

TAF5L: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Belongs to the WD repeat TAF5 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 1q42.13

Molecular Function: histone acetyltransferase activity; protein binding; transcription coactivator activity; transcription factor activity

Biological Process: establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter