Human synaptic Ras GTPase activating protein 1 homolog (rat) ELISA Kit | SYNGAP1 elisa kit
Human Ras GTPase-activating protein SynGAP, SYNGAP1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a major component of the postsynaptic density (PSD), a group of proteins found associated with NMDA receptors at synapses. The encoded protein is phosphorylated by calmodulin-dependent protein kinase II and dephosphorylated by NMDA receptor activation. Defects in this gene are a cause of mental retardation autosomal dominant type 5 (MRD5). [provided by RefSeq, Dec 2009]
Uniprot Description
SynGAP: an excitatory synapse-specific RasGAP. Member of the NMDAR signaling complex in excitatory synapses it may play a role in NMDAR-dependent control of AMPAR potentiation and synaptic plasticity. ERK activation is up-regulated in neurons from SynGAP knockout mice, whereas P38 MAPK function is depressed. May play a critical role in the regulation of neuronal MAPK signaling, AMPAR membrane trafficking, and excitatory synaptic transmission. Interacts with CAMK2A/CAMK2B and MPDZ. Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption. Contains a PH domain and a Ras-GAP domain. Two alternatively spliced isoforms have been described.
Protein type: GAPs; GAPs, Ras
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: cytoplasm; dendritic shaft
Molecular Function: SH3 domain binding
Biological Process: regulation of long-term neuronal synaptic plasticity; regulation of synapse structure and activity; regulation of MAPKKK cascade; Ras protein signal transduction; dendrite development; visual learning; negative regulation of Ras protein signal transduction; regulation of synaptic plasticity; negative regulation of axonogenesis; negative regulation of neuron apoptosis; pattern specification process; receptor clustering
Disease: Mental Retardation, Autosomal Dominant 5
Research Articles on SYNGAP1
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Product Notes
The Human SYNGAP1 syngap1 (Catalog #AAA9323377) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9323377 ELISA Kit recognizes Human SYNGAP1. It is sometimes possible for the material contained within the vial of "synaptic Ras GTPase activating protein 1 homolog (rat), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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