Transcription elongation factor SPT5 (Supt5h) Recombinant Protein | Supt5h recombinant protein

Recombinant Mouse Transcription elongation factor SPT5 (Supt5h) , partial

• Gene Names: Supt5; Spt5; Supt5h; AL033283; AL033321; AU019549
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Transcription elongation factor SPT5 (Supt5h); Recombinant Mouse Transcription elongation factor SPT5 (Supt5h); partial; Supt5h recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1082

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 22094123
• NCBI GeneID: 20924
• NCBI Accession #: NP_038704.1
• NCBI GenBank Nucleotide #: NM_013676.1
• UniProt Accession #: O55201; Q3UJ77; Q3UJH1; Q3UKD7; Q3UM54; Q6PB73; Q6PDP0; Q6PFR4
• Molecular Weight: 98,310 Da
• NCBI Official Full Name: transcription elongation factor SPT5
• NCBI Official Synonym Full Names: suppressor of Ty 5
• NCBI Official Symbol: Supt5
• NCBI Official Synonym Symbols: Spt5; Supt5h; AL033283; AL033321; AU019549
• NCBI Protein Information: transcription elongation factor SPT5
• UniProt Protein Name: Transcription elongation factor SPT5
• UniProt Gene Name: Supt5h
• UniProt Synonym Gene Names: Supt5; DSIF large subunit

Uniprot Description

Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites ().