SuLT1C2 recombinant protein

SuLT1C2, 1-296aa, Human, His tag, E Coli

Cat. Num. AAA203909

• Gene Names: SULT1C2; ST1C1; ST1C2; SULT1C1; humSULTC2
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: SuLT1C2; 1-296aa; Human; His tag; E Coli; Sulfotransferase 1C2 isoform a; humSuLTC2; ST1C1; ST1C2; SuLT1C1; SuLT1C2 recombinant protein

• Host: E Coli
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT
• Concentration: 1.0 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MALTSDLGKQ IKLKEVEGTL LQPATVDNWS QIQSFEAKPD DLLICTYPKA GTTWIQEIVD MIEQNGDVEK CQRAIIQHRH PFIEWARPPQ PSGVEKAKAM PSPRILKTHL STQLLPPSFW ENNCKFLYVA RNAKDCMVSY YHFQRMNHML PDPGTWEEYF ETFINGKVVW GSWFDHVKGW WEMKDRHQIL FLFYEDIKRD PKHEIRKVMQ FMGKKVDETV LDKIVQETSF EKMKENPMTN RSTVSKSILD QSISSFMRKG TVGDWKNHFT VAQNERFDEI YRRKMEGTSI NFCMEL
• Sequence Length: 296

• Applicable Applications for SuLT1C2 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for SuLT1C2 recombinant protein

SuLT1C2, also known as Sulfotransferase 1C2, is a sulfotransferase1 superfamily. It catalyzes the transfer of sulfate from PAPS (3'-phosphoadenosine-5'-phosphosulfate) to phenol-containing compounds, including hormones and neurotransmitters. Two isoforms of SuLT1C2 designated short and long, exist as a result of alternative splicing events. Recombinant human SuLT1C2 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography.

Product Categories/Family for SuLT1C2 recombinant protein

Metabolism

References

Li X., et al. (2000). Biochem. Pharmacol. 60: 1713-1716; Dombrovski L, et al. (2006). Proteins 64: 1091-1094.

NCBI and Uniprot Product Information

• NCBI GI #: 4507305
• NCBI GeneID: 6819
• NCBI Accession #: NP_001047
• NCBI GenBank Nucleotide #: NM_001056.3
• UniProt Accession #: O00338; Q53SG4; B2R813
• Molecular Weight: 37.0 kDa (316aa), confirmed by MALDI-TOF
• NCBI Official Full Name: sulfotransferase 1C2 isoform a
• NCBI Official Synonym Full Names: sulfotransferase family 1C member 2
• NCBI Official Symbol: SULT1C2
• NCBI Official Synonym Symbols: ST1C1; ST1C2; SULT1C1; humSULTC2
• NCBI Protein Information: sulfotransferase 1C2
• UniProt Protein Name: Sulfotransferase 1C2
• Protein Family: Sulfotransferase
• UniProt Gene Name: SULT1C2
• UniProt Synonym Gene Names: SULT1C1; ST1C2; SULT1C#1

NCBI Description

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).