Human syntaxin binding protein 3 ELISA Kit | STXBP3 elisa kit
Human Syntaxin-binding protein 3, STXBP3 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
STXBP3: a vesicle protein that, together with STX4 and VAMP2, regulates the insulin-dependent movement of GLUT4 and the docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. Reduction in its expression using siRNA impairs insulin-stimulated GLUT4 vesicle exocytosis in 3T3-L1 adipocytes. Phosphorylated by the insulin receptor (InsR) at Tyr521 in vitro, and bound and phosphorylated by the activated InsR within adipocytes and skeletal muscle. Tyrosine phosphorylation on residues Y219 and Y521 correlates with its dissociation from STX4. Phosphorylated by PKC in platelets in response to thrombin stimulation, inhibiting its binding to STX4. Interacts directly with DOC2B at the cell membrane, excluding its interaction with STX4, regulating glucose-stimulated insulin secretion. Belongs to the STXBP/unc-18/SEC1 family.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 1p13.3
Cellular Component: specific granule; basolateral plasma membrane; apical plasma membrane; plasma membrane; cytosol
Molecular Function: protein binding; syntaxin binding; syntaxin-1 binding
Biological Process: platelet activation; negative regulation of calcium ion-dependent exocytosis; insulin secretion; protein heterooligomerization; neutrophil degranulation; protein to membrane docking; brain development; glucose transport; blood coagulation; vesicle docking during exocytosis; response to insulin stimulus
Research Articles on STXBP3
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Product Notes
The Human STXBP3 stxbp3 (Catalog #AAA9343381) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9343381 ELISA Kit recognizes Human STXBP3. It is sometimes possible for the material contained within the vial of "syntaxin binding protein 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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