Oligomycin B Antibiotic | Oscp antibiotic

Oligomycin B

Cat. Num. AAA651227

• Gene Names: Oscp; ATPO_DROME; CG4307; DmelCG4307; OSCP
• Purity: Highly Purified; ~ 95% by HPLC
• Synonyms: Oligomycin B; Oscp antibiotic

• Host: Streptomyces sp.
• Purity/Purification: Highly Purified; ~ 95% by HPLC
• Form/Format: Supplied as a white solid.

• CAS Number: 11050-94-5
• Molecular Formula: C45H72O12
• Solubility: Soluble in ethanol, methanol, DMF or DMSO.
• Preparation and Storage: For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for Oscp antibiotic

Oligomycin B, a minor component of the oligomycin complex isolated from selected strains of Streptomyces sp., is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death and also leads to a switch in the death mode from apoptosis to necrosis.

Product Categories/Family for Oscp antibiotic

Biochemicals; Biochem-Antibiotics

NCBI and Uniprot Product Information

• NCBI GI #: 24647056
• NCBI GeneID: 41845
• NCBI Accession #: NP_731995.1
• NCBI GenBank Nucleotide #: NM_169631.1
• UniProt Accession #: Q24439; Q9VFA4
• Molecular Weight: 805.1
• NCBI Official Full Name: oligomycin sensitivity-conferring protein, isoform B
• NCBI Official Synonym Full Names: Oligomycin sensitivity-conferring protein
• NCBI Official Symbol: Oscp
• NCBI Official Synonym Symbols: ATPO_DROME; CG4307; DmelCG4307; OSCP
• NCBI Protein Information: CG4307 gene product from transcript CG4307-RA; ATP synthase OSCP; CG4307-PA; CG4307-PB; F0/F1 ATP synthase OSCP; OLIGOMYCIN SENSITIVITY CONFERRING PROTEIN; Oscp-PA; Oscp-PB; oligimycin sensitive-conferring protein; oligomycin sensitivity-conferring protein
• UniProt Protein Name: ATP synthase subunit O, mitochondrial
• UniProt Gene Name: Oscp
• UniProt Synonym Gene Names: OSCP
• UniProt Entry Name: ATPO_DROME

Uniprot Description

Function: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements.

Subunit structure: F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

Subcellular location: Mitochondrion. Mitochondrion inner membrane.

Sequence similarities: Belongs to the ATPase delta chain family.