Stimulated by retinoic acid gene 6 protein homolog (STRA6) Recombinant Protein | STRA6 recombinant protein

Recombinant Bovine Stimulated by retinoic acid gene 6 protein homolog (STRA6) , partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Stimulated by retinoic acid gene 6 protein homolog (STRA6); Recombinant Bovine Stimulated by retinoic acid gene 6 protein homolog (STRA6); partial; STRA6 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 668

• Species: Bos taurus (Bovine)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 115496352
• NCBI GeneID: 515911
• NCBI Accession #: NP_001069198.1
• NCBI GenBank Nucleotide #: NM_001075730.1
• UniProt Accession #: Q0V8E7; A5PK38
• Molecular Weight: 73,762 Da
• NCBI Official Full Name: receptor for retinol uptake STRA6
• NCBI Official Synonym Full Names: stimulated by retinoic acid 6
• NCBI Official Symbol: STRA6
• NCBI Protein Information: receptor for retinol uptake STRA6; stimulated by retinoic acid gene 6 protein homolog
• UniProt Protein Name: Receptor for retinol uptake STRA6
• Protein Family: Stimulated by retinoic acid gene 6 protein
• UniProt Gene Name: STRA6

Uniprot Description

Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 (PubMed:17255476, PubMed:18419130). Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A. Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin. Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid. STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency. Does not transport retinoic acid ().