STK10 recombinant protein

STK10, Recombinant, Human (Serine/threonine Kinase 10, LOK, Lymphocyte-oriented Kinase, PRO2729, Serine/threonine-protein Kinase 10)

Cat. Num. AAA636167

• Gene Names: STK10; LOK; PRO2729
• Purity: Purified; >=60%
• Synonyms: STK10; Recombinant; Human (Serine/threonine Kinase 10; LOK; Lymphocyte-oriented Kinase; PRO2729; Serine/threonine-protein Kinase 10); STK10 recombinant protein

• Host: Recombinant human STK10, aa1-
• Purity/Purification: Purified; >=60%

• Preparation and Storage: -70 degree C

Testing Data

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Related Product Information for STK10 recombinant protein

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway. STK10 can act on substrates such as myelin basic protein and histone 2A on serine and threonine residues.

Product Categories/Family for STK10 recombinant protein

Molecular Biology; MB-Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 126362971
• NCBI GeneID: 6793
• NCBI Accession #: NP_005981.3
• NCBI GenBank Nucleotide #: NM_005990.3
• UniProt Accession #: O94804; Q6NSK0; Q9UIW4; A6ND35; B2R8F5; B3KMY1
• Molecular Weight: 43.2kD.
• NCBI Official Full Name: serine/threonine-protein kinase 10
• NCBI Official Synonym Full Names: serine/threonine kinase 10
• NCBI Official Symbol: STK10
• NCBI Official Synonym Symbols: LOK; PRO2729
• NCBI Protein Information: serine/threonine-protein kinase 10; lymphocyte-oriented kinase
• UniProt Protein Name: Serine/threonine-protein kinase 10
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: STK10
• UniProt Synonym Gene Names: LOK
• UniProt Entry Name: STK10_HUMAN

NCBI Description

This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]

Uniprot Description

LOK: a protein kinase of the STE20 family. Highly expressed in hematopoietic tissue. May cooperate with SLK to regulate Plk1 function in human cells.

Protein type: Kinase, protein; Protein kinase, STE; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; SLK subfamily

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: cytoplasm; plasma membrane

Molecular Function: identical protein binding; protein serine/threonine kinase activity; protein binding; polo kinase kinase activity; protein homodimerization activity; ATP binding

Biological Process: protein amino acid autophosphorylation; cell cycle; protein amino acid phosphorylation