Metalloprotease stcE (stcE) Recombinant Protein | stcE recombinant protein
Recombinant Escherichia coli O157:H7 Metalloprotease stcE (stcE), partial
NCBI and Uniprot Product Information
Uniprot Description
Virulence factor that contributes to intimate adherence of enterohemorrhagic E.coli (EHEC) O157:H7 to host cells. Is able to cleave the secreted human mucin 7 (MUC7) and the glycoprotein 340 (DMBT1/GP340). Also cleaves human C1 inhibitor (SERPING1), a regulator of multiple inflammatory pathways, and binds and localizes it to bacterial and host cell surfaces, protecting them from complement-mediated lysis. Therefore, the current model proposes two roles for StcE during infection: it acts first as a mucinase, allowing passage of EHEC through the oral cavity by cleaving the salivary glycoproteins that are responsible for bacterial aggregation. Similarly, in the colon, StcE cleaves the glycoproteins that protect the intestinal epithelial surface, allowing EHEC to come into close contact with host cell membranes. Secondly, it acts as an anti-inflammatory agent by localizing SERPING1 to cell membranes.
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Product Notes
The stcE stce (Catalog #AAA1214753) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 296-551aa; Partial. The amino acid sequence is listed below: ELLLHTIDIG MLTTPRDRFD FAKDKEAHRE YFQTIPVSRM IVNNYAPLHL KEVMLPTGEL LTDMDPGNGG WHSGTMRQRI GKELVSHGID NANYGLNSTA GLGENSHPYV VAQLAAHNSR GNYANGIQVH GGSGGGGIVT LDSTLGNEFS HEVGHNYGLG HYVDGFKGSV HRSAENNNST WGWDGDKKRF IPNFYPSQTN EKSCLNNQCQ EPFDGHKFGF DAMAGGSPFS AANRFTMYTP NSSAIIQRFF ENKAVF . It is sometimes possible for the material contained within the vial of "Metalloprotease stcE (stcE), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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