Serine/arginine-Rich Splicing Factor 1 Recombinant Protein | SRSF1 recombinant protein
Recombinant Human Serine/arginine-Rich Splicing Factor 1
Sterile Filtered colorless solution.
Introduction: Serine/arginine-rich splicing factor 1 (SFRS1) belongs to the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. SFRS1 binds to pre-mRNA transcripts and components of the spliceosome, and can either initiate or inhibit splicing depending on the position of the pre-mRNA binding site. The ability of SFRS1 to activate splicing is controlled by phosphorylation and interactions with other splicing factor associated proteins.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. There is a pseudogene of this gene on chromosome 13. [provided by RefSeq, Jun 2014]
Uniprot Description
SF2: a serine-arginine-rich splicing regulatory protein. Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5' and 3' splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice-site-containing pre-mRNA. Extensively phosphorylated on serine residues in the serine-arginine rich region. Three splice variant isoforms have been described. ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors.
Protein type: Spliceosome; RNA-binding; RNA splicing
Chromosomal Location of Human Ortholog: 17q22
Cellular Component: nucleoplasm; cytoplasm; nuclear speck; nucleus
Molecular Function: mRNA binding; RS domain binding; protein binding; RNA binding; nucleotide binding
Biological Process: transcription from RNA polymerase II promoter; nuclear mRNA 5'-splice site recognition; nuclear mRNA splicing, via spliceosome; regulation of translation; mRNA splice site selection; mRNA export from nucleus; regulation of nuclear mRNA splicing, via spliceosome; regulation of transcription, DNA-dependent; in utero embryonic development; RNA splicing; gene expression; mRNA 3'-end processing; mRNA processing; regulation of mRNA stability; termination of RNA polymerase II transcription; cardiac muscle contraction
Research Articles on SRSF1
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Product Notes
The SRSF1 srsf1 (Catalog #AAA146260) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MGSSHHH HHH SSGLVPRGSH MSGGGVIRGP AGNNDCRIYV GNLPPDIRTK DIEDVFYKYG AIRDIDLKNR RGGPPFAFVE FEDPRDAEDA VYGRDGYDYD GYRLRVEFPR SGRGTGRGGG GGGGGGAPRG RYGPPSRRSE NRVVVSGLPP SGSWQDLKDH MREAGDVCYA DVYRDGTGVV EFVRKEDMTY AVRKLDNTKF RSHEGETAYI RVKVDGPRSP SYGRSRSRSR SRSRSRSRSN SRSRSYSPRR SRGSPRYSPR HSRSRSRT.< /u>. It is sometimes possible for the material contained within the vial of "Serine/arginine-Rich Splicing Factor 1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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