Human Serine/arginine-rich splicing factor 1 ELISA Kit | SRSF1 elisa kit
Human Serine/arginine-rich splicing factor 1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. There is a pseudogene of this gene on chromosome 13. [provided by RefSeq, Jun 2014]
Uniprot Description
SF2: a serine-arginine-rich splicing regulatory protein. Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5' and 3' splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice-site-containing pre-mRNA. Extensively phosphorylated on serine residues in the serine-arginine rich region. Three splice variant isoforms have been described. ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 17q22
Cellular Component: nuclear speck; nucleoplasm; nucleus
Molecular Function: mRNA binding; protein binding; RNA binding
Biological Process: alternative nuclear mRNA splicing, via spliceosome; mRNA 3'-end processing; mRNA export from nucleus; mRNA processing; mRNA splice site selection; nuclear mRNA 5'-splice site recognition; nuclear mRNA splicing, via spliceosome; RNA export from nucleus; termination of RNA polymerase II transcription
Research Articles on SRSF1
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Product Notes
The Human SRSF1 srsf1 (Catalog #AAA9428614) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9428614 ELISA Kit recognizes Human SRSF1. It is sometimes possible for the material contained within the vial of "Serine/arginine-rich splicing factor 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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