Mouse serrate RNA effector molecule homolog (Arabidopsis) ELISA Kit | SRRT elisa kit
Mouse Serrate RNA effector molecule homolog, SRRT ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SRRT: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription. Belongs to the ARS2 family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Spliceosome; RNA processing; RNA-binding
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: protein binding; DNA binding
Biological Process: cell proliferation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; RNA-mediated gene silencing; primary microRNA processing
Research Articles on SRRT
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Product Notes
The Mouse SRRT srrt (Catalog #AAA9317722) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9317722 ELISA Kit recognizes Mouse SRRT. It is sometimes possible for the material contained within the vial of "serrate RNA effector molecule homolog (Arabidopsis), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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