Signal recognition particle 72 kDa protein (SRP72) Recombinant Protein | SRP72 recombinant protein
Recombinant Human Signal recognition particle 72 kDa protein (SRP72)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Uniprot Description
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.
Research Articles on SRP72
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Product Notes
The SRP72 srp72 (Catalog #AAA1113769) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-671aa; Full Length of Mature Protein. The amino acid sequence is listed below: ASGGSGGVSV PALWSEVNRY GQNGDFTRAL KTVNKILQIN KDDVTALHCK VVCLIQNGSF KEALNVINTH TKVLANNSLS FEKAYCEYRL NRIENALKTI ESANQQTDKL KELYGQVLYR LERYDECLAV YRDLVRNSQD DYDEERKTNL SAVVAAQSNW EKVVPENLGL QEGTHELCYN TACALIGQGQ LNQAMKILQK AEDLCRRSLS EDTDGTEEDP QAELAIIHGQ MAYILQLQGR TEEALQLYNQ IIKLKPTDVG LLAVIANNII TINKDQNVFD SKKKVKLTNA EGVEFKLSKK QLQAIEFNKA LLAMYTNQAE QCRKISASLQ SQSPEHLLPV LIQAAQLCRE KQHTKAIELL QEFSDQHPEN AAEIKLTMAQ LKISQGNISK ACLILRSIEE LKHKPGMVSA LVTMYSHEED IDSAIEVFTQ AIQWYQNHQP KSPAHLSLIR EAANFKLKYG RKKEAISDLQ QLWKQNPKDI HTLAQLISAY SLVDPEKAKA LSKHLPSSDS MSLKVDVEAL ENSAGATYIR KKGGKVTGDS QPKEQGQGDL KKKKKKKKGK LPKNYDPKVT PDPERWLPMR ERSYYRGRKK GKKKDQIGKG TQGATAGASS ELDASKTVSS PPTSPRPGSA ATVSASTSNI IPPRHQKPAG APATKKKQQQ KKKKGGKGGW . It is sometimes possible for the material contained within the vial of "Signal recognition particle 72 kDa protein (SRP72), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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