Human SLIT-ROBO Rho GTPase activating protein 2 ELISA Kit | SRGAP2 elisa kit
Human SLIT-ROBO Rho GTPase-activating protein 2, SRGAP2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014]
Uniprot Description
SRGAP2: RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia. A chromosomal aberration disrupting SRGAP2 has been found in a patient with early infantile epileptic encephalopathy. Balanced translocation t(1;9)(q32;q13).
Protein type: GAPs, Rac/Rho; Motility/polarity/chemotaxis; Mitochondrial; GAPs
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: postsynaptic membrane; lamellipodium; cytoplasm; postsynaptic density; plasma membrane; phagocytic vesicle; cell junction; cytosol; nucleus
Molecular Function: protein binding; protein homodimerization activity; Rac GTPase binding
Biological Process: cell proliferation; actin filament severing; axon guidance; regulation of small GTPase mediated signal transduction; extension of a leading process involved in cell locomotion in cerebral cortex radial glia guided migration; filopodium formation; small GTPase mediated signal transduction; neurite morphogenesis
Research Articles on SRGAP2
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Product Notes
The Human SRGAP2 srgap2 (Catalog #AAA9336572) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9336572 ELISA Kit recognizes Human SRGAP2. It is sometimes possible for the material contained within the vial of "SLIT-ROBO Rho GTPase activating protein 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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