Steroid Receptor RNA Activator 1 Recombinant Protein | SRA1 recombinant protein
Recombinant Human Steroid Receptor RNA Activator 1
Sterile Filtered clear solution.
Introduction: Steroid receptor RNA activator 1 (SRA1) occurs as both an RNA transcript and as constantly expressed proteins. In addition, SRA1 mediates transcriptional coactivation of steroid receptors ligand-dependently via the steroid-binding domain (AF-2). SRA1 augments cellular proliferation and differentiation and stimulates apoptosis in vivo. SRA1 has a role in tumorigenesis. SRA1 participates in some activities such as: metabolism, adipogenesis and chromatin organization.
NCBI and Uniprot Product Information
NCBI Description
Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012]
Uniprot Description
SRA1: Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand- dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis. Belongs to the SRA1 family.
Protein type: Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 5q31.3
Cellular Component: nucleoplasm; microtubule cytoskeleton; intercellular bridge; cytoplasm; plasma membrane; nucleus; ribonucleoprotein complex
Molecular Function: protein binding; ligand-dependent nuclear receptor transcription coactivator activity; transcription coactivator activity
Biological Process: regulation of apoptosis; cell proliferation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; apoptosis; cell differentiation
Research Articles on SRA1
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Product Notes
The SRA1 sra1 (Catalog #AAA146089) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MGSSHHH HHH SSGLVPRGSH MGSVGS GPAS GVEPTSFPVE SEAVMEDVLR PLEQALEDCR GHTRKQVCDD ISRRLALLQE QWAGGKLSIP VKKRMA LLVQ ELSSHRWDAA DDIHRSLMVD HVTEVSQWMV GVKRLIAEKR SLFSEEAANE EKSAATAEKN HTIPGFQQAS . It is sometimes possible for the material contained within the vial of "Steroid Receptor RNA Activator 1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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