Sequestosome-1 (Sqstm1) Recombinant Protein | Sqstm1 recombinant protein

Recombinant Rat Sequestosome-1 (Sqstm1)

Cat. Num. AAA1196146

• Gene Names: Sqstm1; Osi; ZIP; ZIP3
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Sequestosome-1 (Sqstm1); Recombinant Rat Sequestosome-1 (Sqstm1); Sqstm1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 2-439, Full length protein
• Sequence: ASLTVKAYLLGKEEAAREIRRFSFCFSPEPEAEAAAGPGPCERLLSRVAVLFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRREHRPPCAQEARSMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHREHSKLIFPNPFGHLSDSFSHSRWLRKLKHGHFGWPGWEMGPPGNWSPRPPRAGDGRPCPTAESASAPSEDPNVNFLKNVGESVAAALSPLGIEVDIDVEHGGKRSRLTPTSAESSSTGTEDKSGTQPSSCSSEVSKPDGAGEGPAQSLTEQMKKIALESVGQPEELMESDNCSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEADPRLIESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL
• Sequence Length: 438

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Sqstm1 recombinant protein

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding
adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

NCBI and Uniprot Product Information

• NCBI GI #: 31581536
• NCBI GeneID: 113894
• NCBI Accession #: NP_787037.2
• NCBI GenBank Nucleotide #: NM_175843.4
• UniProt Accession #: O08623; Q8CH59
• Molecular Weight: 26,067 Da
• NCBI Official Full Name: sequestosome-1 isoform 1
• NCBI Official Synonym Full Names: sequestosome 1
• NCBI Official Symbol: Sqstm1
• NCBI Official Synonym Symbols: Osi; ZIP; ZIP3
• NCBI Protein Information: sequestosome-1
• UniProt Protein Name: Sequestosome-1
• Protein Family: Sequestosome
• UniProt Gene Name: Sqstm1
• UniProt Synonym Gene Names: Zip; PKC-zeta-interacting protein

NCBI Description

interacts with PKC-zeta and GABA(C) receptors to form ternary postsynaptic complex in the retina [RGD, Feb 2006]

Uniprot Description

Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (). Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery (). Involved in midbody ring degradation (). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:11244088, PubMed:11500922). May play a role in titin/TTN downstream signaling in muscle cells (). May regulate signaling cascades through ubiquitination (). Adapter that mediates the interaction between TRAF6 and CYLD (). May be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels (). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport ().