27.5 kDa virulence protein (mkaD) Recombinant Protein | mkaD recombinant protein
Recombinant Salmonella typhimurium 27.5 kDa virulence protein (mkaD)
Gene Names
spvC; spvB
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
27.5 kDa virulence protein (mkaD); Recombinant Salmonella typhimurium 27.5 kDa virulence protein (mkaD); mkaD recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
2-241
, Full length protein
Sequence
PINRPNLNLNIPPLNIVAAYDGAEIPSTNKHLKNNFNSLHNQMRKMPVSHFKEALDVPDYSGMRQSGFFAMSQGFQLNNHGYDVFIHARRESPQSQGKFAGDKFHISVLRDMVPQAFQALSGLLFSEDSPVDKWKVTDMEKVVQQARVSLGAQFTLYIKPDQENSQYSASFLHKTRQFIECLESRLSENGVISGQCPESDVHPENWKYLSYRNELRSGRDGGEMQRQALREEPFYRLMTE
Species
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
27,646 Da
NCBI Official Full Name
Salmonella plasmid virulence: hydrophilic protein (plasmid)
NCBI Official Symbol
spvC
NCBI Official Synonym Symbols
spvB
NCBI Protein Information
Salmonella plasmid virulence: hydrophilic protein
UniProt Protein Name
MAPK phosphothreonine lyase
UniProt Gene Name
spvC
UniProt Synonym Gene Names
mkaD; vsdD
Uniprot Description
Secreted effector that irreversibly inactivates host MAP kinases by catalyzing the dephosphorylation of the phosphothreonine residue in the pT-X-pY motif in MAPK2/ERK2, MAPK3/ERK1, and p38, via a beta-elimination reaction leading to a dehydrobutyrine residue. Is also able to remove the phosphate group from phospho-JNK in vitro, but JNK may not be a substrate in vivo. Could help suppress localized proinflammatory responses at infection foci in the spleen and liver, and thereby facilitate bacterial growth.
Research Articles on mkaD
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Product Notes
The mkaD spvc (Catalog #AAA1211221) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-241 , Full length protein. The amino acid sequence is listed below: PINRPNLNLN IPPLNIVAAY DGAEIPSTNK HLKNNFNSLH NQMRKMPVSH FKEALDVPDY SGMRQSGFFA MSQGFQLNNH GYDVFIHARR ESPQSQGKFA GDKFHISVLR DMVPQAFQAL SGLLFSEDSP VDKWKVTDME KVVQQARVSL GAQFTLYIKP DQENSQYSAS FLHKTRQFIE CLESRLSENG VISGQCPESD VHPENWKYLS YRNELRSGRD GGEMQRQALR EEPFYRLMTE. It is sometimes possible for the material contained within the vial of "27.5 kDa virulence protein (mkaD), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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