NCBI and Uniprot Product Information
Uniprot Description
COL7A1: the alpha chain of type VII collagen, an extra-cellular basement membrane protein restricted to the zone beneath stratified squamous epithelia. Type VII collagen fibrils are composed of three identical alpha collagen chains. Forms anchoring fibrils, which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. Dystrophic epidermolysis bullosa can result from defects in this protein or an autoimmune response made to type VII collagen. Homotrimer. Interacts with MIA3, facilitating its loading into transport carriers and subsequent secretion. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Extracellular matrix; Inhibitor; Secreted
Cellular Component: proteinaceous extracellular matrix; extracellular space; collagen; extracellular region; basement membrane
Molecular Function: serine-type endopeptidase inhibitor activity; identical protein binding; protease inhibitor activity
Biological Process: negative regulation of peptidase activity; cell adhesion
Research Articles on COL7
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Product Notes
The Porcine COL7 col7a1 (Catalog #AAA2513164) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2513164 ELISA Kit recognizes Porcine COL7. It is sometimes possible for the material contained within the vial of "COL7, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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