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Serine Protease Inhibitor Kazal-Type 4 Recombinant Protein | SPINK4 recombinant protein
Recombinant Human Serine Protease Inhibitor Kazal-Type 4 Protein
Gene Names
SPINK4; PEC60; HEL136; PEC-60
Purity
>95% as determined by reducing SDS-PAGE.
Synonyms
Serine Protease Inhibitor Kazal-Type 4; Recombinant Human Serine Protease Inhibitor Kazal-Type 4 Protein; Peptide PEC-60 Homolog; SPINK4; SPINK4 recombinant protein
Host
Human Cells
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Form/Format
Lyophilized from a 0.2 mum filtered solution of PBS, 1mM EDTA, 5% Mannitol, 7.4.
Sequence Length
86
Species
Human
Endotoxin
<1.0 EU per ug as determined by LAL test.
Fragment
Gly27-Cys86
Fusion Tag
C-6His
Preparation and Storage
Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
SDS-Page
SDS-Page
Related Product Information for SPINK4 recombinant protein
Protein Construction: Recombinant Human Serine Protease Inhibitor Kazal-Type 4 is produced by our Mammalian expression system and the target gene encoding Gly27-Cys86 is expressed with a 6His tag at the C-terminus.
Background: Serine Protease Inhibitor Kazal-Type 4 (SPINK4) is a secreted protein containing one Kazal-like domain. SPINK4 is a member of the SPINK protein family. The gene family of serine protease inhibitors of the Kazal type (SPINK) are functional and positional candidate genes for celiac disease (CD). SPINK1 plays an important role in protecting the pancreas against excessive trypsinogen activation. It is a potent natural inhibitor of pancreatic trypsin activity. SPINK1 mutations are associated with the development of acute and chronic pancreatitis and have been detected in all forms of chronic pancreatitis. SPINK2 functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged in fertility. The SPINK2 protein contains a typical Kazal domain composed by six cysteine residues forming three disulfide bridges. SPINK9 was identified in human skin. Its expression was strong in palmar epidermis, but not detectable or very low in non palmoplantar skin.
Background: Serine Protease Inhibitor Kazal-Type 4 (SPINK4) is a secreted protein containing one Kazal-like domain. SPINK4 is a member of the SPINK protein family. The gene family of serine protease inhibitors of the Kazal type (SPINK) are functional and positional candidate genes for celiac disease (CD). SPINK1 plays an important role in protecting the pancreas against excessive trypsinogen activation. It is a potent natural inhibitor of pancreatic trypsin activity. SPINK1 mutations are associated with the development of acute and chronic pancreatitis and have been detected in all forms of chronic pancreatitis. SPINK2 functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged in fertility. The SPINK2 protein contains a typical Kazal domain composed by six cysteine residues forming three disulfide bridges. SPINK9 was identified in human skin. Its expression was strong in palmar epidermis, but not detectable or very low in non palmoplantar skin.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Molecular Mass: 7.7kDa
Actual Protein Molecular Mass: 12kDa
Actual Protein Molecular Mass: 12kDa
NCBI Official Full Name
serine protease inhibitor Kazal-type 4
NCBI Official Synonym Full Names
serine peptidase inhibitor, Kazal type 4
NCBI Official Symbol
SPINK4
NCBI Official Synonym Symbols
PEC60; HEL136; PEC-60
NCBI Protein Information
serine protease inhibitor Kazal-type 4
UniProt Protein Name
Serine protease inhibitor Kazal-type 4
Protein Family
UniProt Gene Name
SPINK4
Research Articles on SPINK4
1. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
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Product Notes
The SPINK4 spink4 (Catalog #AAA2556659) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Serine Protease Inhibitor Kazal-Type 4, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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