Human spastic paraplegia 11 (autosomal recessive) ELISA Kit | SPG11 elisa kit
Human Spatacsin, SPG11 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Uniprot Description
SPG11: Defects in SPG11 are the cause of spastic paraplegia autosomal recessive type 11 (SPG11). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 15q14
Cellular Component: lysosomal membrane; cytoplasm; integral to membrane; nucleolus; plasma membrane; cytoplasmic vesicle; cytosol
Molecular Function: protein binding
Disease: Spastic Paraplegia 11, Autosomal Recessive
Research Articles on SPG11
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Product Notes
The Human SPG11 spg11 (Catalog #AAA9328072) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9328072 ELISA Kit recognizes Human SPG11. It is sometimes possible for the material contained within the vial of "spastic paraplegia 11 (autosomal recessive), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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