Mitochondria-eating protein (Spata18) Recombinant Protein | Spata18 recombinant protein

Recombinant Rat Mitochondria-eating protein (Spata18)

Cat. Num. AAA1332370

• Gene Names: Spata18; spetex-1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Mitochondria-eating protein (Spata18); Recombinant Rat Mitochondria-eating protein (Spata18); Spata18 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-568, full length protein
• Sequence: MAENLKKLAQSESFLSLQDKVCFWANDYQTNSCDQNLNCCIELIEQVAKVQAQLFAILTATAQEGGHNEGVETIKSRLLPLLQTSFSSLGVGKIIQTEIRPIQDFQLRSKNRQSSLDQEQQQSDGDSFIESQPTQVQDDLTESGKNLEGTKNGSAISLLAAEEEINQLKKQLKSLQAQEDARHKTSENRRAEISRTDRRPSGKRNSERPQDVVSNYEKHLKNLKDEIAVLSAEKSGLQASHRQTRSRSPSPGPRGPRGPRGRRRSRSHSRSHSRSHSRSHSHSNSHSNSRSNSPCTTVAKIRSPSPNRSKMSSVARKAALLSRFSDAYSQARLDAQCLLRRCIDRAETVQRIIYIATVEAFHIAKMAFRHFKIRVRKMLTPSHVGSNDFETAVSDYIVCHLDLYDSQSSVNDVIRAMNVNPKISFPPEVDFCLLTDFIQEICCIAFAMQSLEPPLDIAFGADGEVFNEAKYRRSYDSDFTAPLVFYHVWPALMENDCVIMKGEAVTKRGAFWTTVRPVMRCRSRSLSPICPRSRFGISTVHSCVTIPADDLVSRSRSPSPIRCTFARY
• Sequence Length: 568

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 51491896
• NCBI GeneID: 289586
• NCBI Accession #: NP_955406.2
• NCBI GenBank Nucleotide #: NM_199374.2
• UniProt Accession #: Q6AYL6; Q764P0; D3ZEU0
• Molecular Weight: 62,633 Da
• NCBI Official Full Name: mitochondria-eating protein
• NCBI Official Synonym Full Names: spermatogenesis associated 18
• NCBI Official Symbol: Spata18
• NCBI Official Synonym Symbols: spetex-1
• NCBI Protein Information: mitochondria-eating protein
• UniProt Protein Name: Mitochondria-eating protein
• Protein Family: Mitochondria-eating protein
• UniProt Gene Name: Spata18
• UniProt Synonym Gene Names: Mieap; Spetex1; Spetex-1

NCBI Description

may play a role in differentiation of late elongate spermatids to mature spermatozoa [RGD, Feb 2006]

Uniprot Description

Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (). May have a role in spermatogenesis, especially in cell differentiation from late elongate spermatids to mature spermatozoa.