SDS-Page
(Recombinant SP140 (688-862) protein gel. SP140 (688-862) protein was run on a 12.5% SDS-PAGE gel and stained with Coomassie Blue. MW: 26.9 kDa Purity: > 90%)
SP140 recombinant protein
Recombinant SP140 (688-862) protein
Shipping Temp: Dry Ice
SDS-Page
(Recombinant SP140 (688-862) protein gel. SP140 (688-862) protein was run on a 12.5% SDS-PAGE gel and stained with Coomassie Blue. MW: 26.9 kDa Purity: > 90%)
SDS-Page
(Recombinant SP140 (688-862) protein gel. SP140 (688-862) protein was run on a 12.5% SDS-PAGE gel and stained with Coomassie Blue. MW: 26.9 kDa Purity: > 90%)
Testing Data
(HTRF Assay for Recombinant SP140 (688-862) protein activity. 3 uM histone peptide H3K14ac was incubated with SP140 (688-862) in reaction buffer including 50 mM HEPES-NaOH pH 7.0, 0.1% BSA for 1 hour at room temperature. Anti-DYKDDDDK antibody was used to detect reaction products.)
Testing Data
(HTRF Assay for Recombinant SP140 (688-862) protein activity. 3 uM histone peptide H3K14ac was incubated with SP140 (688-862) in reaction buffer including 50 mM HEPES-NaOH pH 7.0, 0.1% BSA for 1 hour at room temperature. Anti-DYKDDDDK antibody was used to detect reaction products.)
Testing Data
(HTRF Assay for Recombinant SP140 (688-862) protein activity. 3 uM histone peptide H3K14ac was incubated with SP140 (688-862) in reaction buffer including 50 mM HEPES-NaOH pH 7.0, 0.1% BSA for 1 hour at room temperature. Anti-DYKDDDDK antibody was used to detect reaction products.)
Testing Data
(HTRF Assay for Recombinant SP140 (688-862) protein activity. 3 uM histone peptide H3K14ac was incubated with SP140 (688-862) in reaction buffer including 50 mM HEPES-NaOH pH 7.0, 0.1% BSA for 1 hour at room temperature. Anti-DYKDDDDK antibody was used to detect reaction products.)
Background: SP140 nuclear body protein (SP140) is a component of the nuclear body that may be involved in trafficking between the nucleus and the cytoplasm. SP140 contains one HSR domain, one PHD-type zinc finger, a bromodomain and one SAND domain. The bromodomain functions as a 'reader' of epigenetic histone marks and regulates chromatin structure and gene expression by linking associated proteins to the recognized acetylated nucleosomal targets. SP140 may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection.
NCBI and Uniprot Product Information
Uniprot Description
SP140: Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: nucleoplasm; PML body; cytoplasm; nuclear envelope; nucleus
Molecular Function: protein binding; DNA binding; zinc ion binding; chromatin binding; transcription factor activity
Biological Process: chromatin remodeling; regulation of transcription, DNA-dependent; defense response
Research Articles on SP140
Similar Products
Product Notes
The SP140 sp140 (Catalog #AAA388162) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SP140, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
