SorLA Blocking Peptide | SORL1 blocking peptide

SorLA Blocking Peptide

Cat. Num. AAA9622445

• Gene Names: SORL1; LR11; LRP9; SORLA; gp250; SorLA-1; C11orf32
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: SorLA; SorLA Blocking Peptide; C11orf32; FLJ21930; FLJ39258; gp250; LDLR relative with 11 ligand binding repeats; LDLR relative with 11 ligand-binding repeats; Low density lipoprotein receptor relative with 11 ligand binding repeats; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; LR 11; LR11; LRP 9; LRP9; Mosaic protein LR11; SORL 1; SORL_HUMAN; SORL1; SorLA 1; SorLA-1; Sortilin related receptor; Sortilin related receptor L(DLR class) A repeats containing; Sortilin-related receptor; Sorting protein related receptor containing LDLR class A repeats; Sorting protein-related receptor containing LDLR class A repeats; SORL1 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for SORL1 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SORL1 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 4507157
• NCBI GeneID: 6653
• NCBI Accession #: NP_003096.1
• NCBI GenBank Nucleotide #: NP_003096.1
• UniProt Accession #: Q92673; Q92856; B2RNX7
• Molecular Weight: 248,426 Da
• NCBI Official Full Name: sortilin-related receptor preproprotein
• NCBI Official Synonym Full Names: sortilin-related receptor, L(DLR class) A repeats containing
• NCBI Official Symbol: SORL1
• NCBI Official Synonym Symbols: LR11; LRP9; SORLA; gp250; SorLA-1; C11orf32
• NCBI Protein Information: sortilin-related receptor; mosaic protein LR11; LDLR relative with 11 ligand-binding repeats; sortilin-related receptor, L(DLR class) A repeats-containing; sorting protein-related receptor containing LDLR class A repeats; low-density lipoprotein receptor
• UniProt Protein Name: Sortilin-related receptor
• Protein Family: Sortilin-related receptor
• UniProt Gene Name: SORL1
• UniProt Synonym Gene Names: C11orf32; LDLR relative with 11 ligand-binding repeats; LR11; SorLA
• UniProt Entry Name: SORL_HUMAN

NCBI Description

This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.[provided by RefSeq, Sep 2010]

Uniprot Description

SORL1: Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction. Belongs to the VPS10-related sortilin family. SORL1 subfamily.

Protein type: Cell surface; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23.2-q24.2

Cellular Component: Golgi apparatus; extracellular space; Golgi cisterna; integral to plasma membrane; endoplasmic reticulum; early endosome; trans-Golgi network; multivesicular body; recycling endosome; cell soma; membrane; nuclear envelope lumen; endosome

Molecular Function: ADP-ribosylation factor binding; protein binding; transmembrane receptor activity; beta-amyloid binding; low-density lipoprotein binding

Biological Process: cholesterol metabolic process; negative regulation of MAP kinase activity; receptor-mediated endocytosis; protein targeting to lysosome; cell migration; protein maturation; lipid transport; signal transduction; negative regulation of neurogenesis; negative regulation of protein oligomerization; cell proliferation; regulation of smooth muscle cell migration; positive regulation of protein catabolic process; post-Golgi vesicle-mediated transport; protein targeting to Golgi; negative regulation of protein binding; protein retention in Golgi; protein targeting

Disease: Alzheimer Disease