Mouse sorbin and SH3 domain containing 3 ELISA Kit | SORBS3 elisa kit
Mouse Vinexin, SORBS3 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
vinexin: an adapter protein that contains three SH3 domains and is involved in the reorganization of actin cytoskeleton. Two alternatively spliced isoforms have been described. Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain. Both isoforms localize at focal adhesion and cell-cell adhesion sites; vinexin beta was also found in the nucleus. Interacts with DLG5 through its third SH3 domain. Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC) through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with SAFB2.
Protein type: Motility/polarity/chemotaxis; Cell adhesion; Nuclear receptor co-regulator; Adaptor/scaffold
Cellular Component: cytoskeleton; focal adhesion; cytoplasm; cell junction; nucleus
Molecular Function: protein binding; transcription factor binding; vinculin binding
Biological Process: positive regulation of MAPKKK cascade; positive regulation of stress fiber formation; actin filament organization; negative regulation of transcription from RNA polymerase II promoter; cell adhesion; cell-substrate adhesion
Research Articles on SORBS3
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Product Notes
The Mouse SORBS3 sorbs3 (Catalog #AAA9324410) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9324410 ELISA Kit recognizes Mouse SORBS3. It is sometimes possible for the material contained within the vial of "sorbin and SH3 domain containing 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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