Small nuclear ribonucleoprotein-associated protein N (Snrpn) Recombinant Protein | Snrpn recombinant protein

Recombinant Mouse Small nuclear ribonucleoprotein-associated protein N (Snrpn)

Cat. Num. AAA961985

• Gene Names: Snrpn; SMN; Peg4; sm-D; HCERN3; snRNP-N; 2410045I01Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Small nuclear ribonucleoprotein-associated protein N (Snrpn); Recombinant Mouse Small nuclear ribonucleoprotein-associated protein N (Snrpn); Snrpn recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-240, Full length protein
• Sequence: MTVGKSSKMLQHIDYRMRCILQDGRIFIGTFKAFDKHMNLILCDCDEFRKIKPKNAKQPEREEKRVLGLVLLRGENLVSMTVEGPPPKDTGIARVPLAGAAGGPGVGRAAGRGVPAGVPIPQAPAGLAGPVRGVGGPSQQVMTPQGRGTVAAAAVAATASIAGAPTQYPPGRGTPPPPVGRATPPPGIMAPPPGMRPPMGPPIGLPPARGTPIGMPPPGMRPPPPGIRGPPPPGMRPPRP
• Sequence Length: 240

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Snrpn recombinant protein

This protein is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB
SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5 untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5 UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure.

NCBI and Uniprot Product Information

• NCBI GI #: 133725810
• NCBI GeneID: 20646
• NCBI Accession #: NP_001076430.1
• NCBI GenBank Nucleotide #: NM_001082961.2
• UniProt Accession #: P63163; P14648; P17135
• Molecular Weight: 24,614 Da
• NCBI Official Full Name: small nuclear ribonucleoprotein-associated protein N
• NCBI Official Synonym Full Names: small nuclear ribonucleoprotein N
• NCBI Official Symbol: Snrpn
• NCBI Official Synonym Symbols: SMN; Peg4; sm-D; HCERN3; snRNP-N; 2410045I01Rik
• NCBI Protein Information: small nuclear ribonucleoprotein-associated protein N
• UniProt Protein Name: Small nuclear ribonucleoprotein-associated protein N
• Protein Family: Small nuclear ribonucleoprotein-associated protein
• UniProt Gene Name: Snrpn
• UniProt Synonym Gene Names: Smn; snRNP-N; Sm-D; Sm-N; SmN

NCBI Description

This locus represents a paternally-expressed imprinted gene that encodes a component of the small nuclear ribonucleoprotein complex, which functions in pre-mRNA processing. Genomic and genetic changes in this region result in growth defects and lethality; the corresponding region in human is the critical region for Prader-Willi Syndrome. Alternative promoter use and alternative splicing result in a multitude of transcript variants encoding the same protein. Transcript variants may be bicistronic and also encode the SNRPN upstream reading frame protein (Snurf) from an upstream open reading frame. In addition, long spliced transcripts for small nucleolar RNA host gene 14 (Snhg14) may originate from the promoters at this locus and incorporate exons shared with this gene. [provided by RefSeq, Mar 2017]

Uniprot Description

May be involved in tissue-specific alternative RNA processing events.