Alpha-synuclein Recombinant Protein | SYUA recombinant protein

Recombinant Human Alpha-synuclein protein

Cat. Num. AAA9420684

• Gene Names: SNCA; PD1; NACP; PARK1; PARK4
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Alpha-synuclein; Recombinant Human Alpha-synuclein protein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP; SYUA recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Full Length, 1-140aa

• Tag Info: His-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for SYUA recombinant protein

May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.

NCBI and Uniprot Product Information

• NCBI GI #: 4507109
• NCBI GeneID: 6622
• NCBI Accession #: NP_000336.1
• NCBI GenBank Nucleotide #: NM_000345.3
• UniProt Accession #: P37840; Q13701; Q4JHI3; Q6IAU6; A8K2A4
• Molecular Weight: 18.6kD
• NCBI Official Full Name: alpha-synuclein isoform NACP140
• NCBI Official Synonym Full Names: synuclein alpha
• NCBI Official Symbol: SNCA
• NCBI Official Synonym Symbols: PD1; NACP; PARK1; PARK4
• NCBI Protein Information: alpha-synuclein
• UniProt Protein Name: Alpha-synuclein
• Protein Family: Alpha-synuclein
• UniProt Gene Name: SNCA
• UniProt Synonym Gene Names: NACP; PARK1; NACP

NCBI Description

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]

Uniprot Description

SNCA: a member of the synuclein family that is abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Aggregated forms of the protein are implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Three alternatively spliced human isoforms have been identified.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 4q22.1

Cellular Component: actin cytoskeleton; axon; cell cortex; cytoplasm; cytosol; extracellular region; extracellular space; growth cone; inclusion body; lysosome; membrane; mitochondrial respiratory chain complex I; mitochondrion; nucleus; perinuclear region of cytoplasm; plasma membrane; platelet alpha granule membrane

Molecular Function: alpha-tubulin binding; calcium ion binding; caspase inhibitor activity; copper ion binding; fatty acid binding; ferrous iron binding; histone binding; Hsp70 protein binding; identical protein binding; kinesin binding; magnesium ion binding; oxidoreductase activity; phospholipid binding; phosphoprotein binding; protein binding; tau protein binding; zinc ion binding

Biological Process: calcium ion homeostasis; caspase activation; cellular protein metabolic process; dopamine biosynthetic process; dopamine uptake; microglial cell activation; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of dopamine uptake; negative regulation of exocytosis; negative regulation of histone acetylation; negative regulation of microtubule polymerization; negative regulation of monooxygenase activity; negative regulation of norepinephrine uptake; negative regulation of serotonin uptake; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transporter activity; positive regulation of apoptosis; positive regulation of endocytosis; positive regulation of peptidyl-serine phosphorylation; positive regulation of receptor recycling; positive regulation of release of sequestered calcium ion into cytosol; protein destabilization; receptor internalization; regulation of dopamine secretion; response to iron(II) ion; response to lipopolysaccharide; response to magnesium ion; synaptic vesicle endocytosis

Disease: Dementia, Lewy Body; Parkinson Disease 1, Autosomal Dominant; Parkinson Disease 4, Autosomal Dominant