Rat single-strand-selective monofunctional uracil-DNA glycosylase 1 ELISA Kit | SMUG1 elisa kit
Rat Single-strand selective monofunctional uracil DNA glycosylase, SMUG1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
involved in the repair of 5-formyluracil and other oxidized and deaminated base lesions [RGD, Feb 2006]
Uniprot Description
Function: Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. The general order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at the low salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA.1 PublicationManual assertion based on experiment in:Ref.1
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Product Notes
The Rat SMUG1 smug1 (Catalog #AAA9342269) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9342269 ELISA Kit recognizes Rat SMUG1. It is sometimes possible for the material contained within the vial of "single-strand-selective monofunctional uracil-DNA glycosylase 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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