SDS-PAGE
SMPDL3A recombinant protein
Recombinant Human SMPDL3A Protein (His tag)
Gene Names
SMPDL3A; ASM3A; ASML3a; yR36GH4.1
Purity
> 95 % as determined by SDS-PAGE
Synonyms
SMPDL3A; Recombinant Human SMPDL3A Protein (His tag); ASML3A; SMPDL3A recombinant protein
Host
Human Cells
Purity/Purification
> 95 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
322
Application Notes
The recombinant human SMPDL3A consists of 442 amino acids and predicts a molecular mass of 50.3 KDa. It migrates as an approximately 51 KDa band in SDS-PAGE under reducing conditions.
Predicted N Terminal
Leu 23
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for SMPDL3A recombinant protein
Background: SMPDL3A gene is a novel liver X receptor (LXR) -regulated gene, with an LXR response element within its promoter. The induction of SMPDL3A is LXR-dependent and is restricted to human blood cells with no induction observed in mouse cellular systems. LXR alpha and LXRbeta function as physiological sensors of cholesterol metabolites (oxysterols), regulating key genes involved in cholesterol and lipid metabolism. LXRs have been extensively studied in both human and rodent cell systems, revealing their potential therapeutic value in the contexts of atherosclerosis and inflammatory diseases. The LXR genome landscape has been investigated in murine macrophages but not in human THP-1 cells, which represent one of the frequently used monocyte/macrophage cell systems to study immune responses.
Description: A DNA sequence encoding the human SMPDL3A (Q92484) (Met1-Tyr453) was expressed with a polyhistidine tag at the C-terminus.
Description: A DNA sequence encoding the human SMPDL3A (Q92484) (Met1-Tyr453) was expressed with a polyhistidine tag at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
37,285 Da
NCBI Official Full Name
acid sphingomyelinase-like phosphodiesterase 3a isoform b
NCBI Official Synonym Full Names
sphingomyelin phosphodiesterase acid like 3A
NCBI Official Symbol
SMPDL3A
NCBI Official Synonym Symbols
ASM3A; ASML3a; yR36GH4.1
NCBI Protein Information
acid sphingomyelinase-like phosphodiesterase 3a
UniProt Protein Name
Acid sphingomyelinase-like phosphodiesterase 3a
Protein Family
UniProt Gene Name
SMPDL3A
UniProt Synonym Gene Names
ASML3A; ASM-like phosphodiesterase 3a
Uniprot Description
SMPDL3A: Belongs to the acid sphingomyelinase family.
Protein type: EC 3.1.4.-; Phosphodiesterase; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6q22.31
Cellular Component: extracellular space
Molecular Function: phosphoric diester hydrolase activity; protein binding; sphingomyelin phosphodiesterase activity; zinc ion binding
Biological Process: nucleoside triphosphate catabolic process; sphingomyelin catabolic process
Research Articles on SMPDL3A
Similar Products
Product Notes
The SMPDL3A smpdl3a (Catalog #AAA2545282) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant human SMPDL3A consists of 442 amino acids and predicts a molecular mass of 50.3 KDa. It migrates as an approximately 51 KDa band in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the SMPDL3A smpdl3a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SMPDL3A, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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