Human Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) ELISA Kit | SMG7 elisa kit
Human Protein SMG7, SMG7 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]
Uniprot Description
SMG7: Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1q25
Cellular Component: intermediate filament cytoskeleton; cytoplasm; nucleus; cytosol
Molecular Function: protein binding; protein phosphatase 2A binding
Biological Process: mRNA export from nucleus; regulation of dephosphorylation; mRNA catabolic process, nonsense-mediated decay; gene expression
Research Articles on SMG7
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Product Notes
The Human SMG7 smg7 (Catalog #AAA9336288) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9336288 ELISA Kit recognizes Human SMG7. It is sometimes possible for the material contained within the vial of "Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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