SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 (Smarcd3) Recombinant Protein | Smarcd3 recombinant protein
Recombinant Mouse SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 (Smarcd3)
SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF
SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
NCBI and Uniprot Product Information
Uniprot Description
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:22952240, PubMed:26601204). Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523).
Research Articles on Smarcd3
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Product Notes
The Smarcd3 smarcd3 (Catalog #AAA1311330) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-483, full length protein. The amino acid sequence is listed below: AADEVAGGAR KATKSKLFEF LVHGVRPGMP SGARMPHQGA PMGPPGSPYM GSPAVRPGLA PAGMEPARKR AAPPPGQSQA QGQGQPVPTA PARSRSAKRR KMADKILPQR IRELVPESQA YMDLLAFERK LDQTIMRKRV DIQEALKRPM KQKRKLRLYI SNTFNPAKPD AEDSDGSIAS WELRVEGKLL DDPSKQKRKF SSFFKSLVIE LDKDLYGPDN HLVEWHRTPT TQETDGFQVK RPGDLSVRCT LLLMLDYQPP QFKLDPRLAR LLGLHTQSRS AIVQALWQYV KTNRLQDSHD KEYINGDKYF QQIFDCPRLK FSEIPQRLTA LLLPPDPIVI NHVISVDPSD QKKTACYDID VEVEEPLKGQ MSSFLLSTAN QQEISALDSK IHETIESINQ LKIQRDFMLS FSRDPKGYVQ DLLRSQSRDL KVMTDVAGNP EEERRAEFYH QPWSQEAVSR YFYCKIQQRR QELEQSLVVR NT. It is sometimes possible for the material contained within the vial of "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 (Smarcd3), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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