Actin Alpha 2 (ACTa2) Small Molecule | ACTa2 small molecule

OVA Conjugated Actin Alpha 2, Smooth Muscle (ACTa2)

Cat. Num. AAA2105197

• Gene Names: ACTA2; ACTSA
• Applications: SDS-Page, Western Blot
• Purity: > 90%
• Synonyms: Actin Alpha 2 (ACTa2); OVA Conjugated Actin Alpha 2; Smooth Muscle (ACTa2); ACT-A2; ACTSA; ACTVS; Asma; GIG46; Cell growth-inhibiting gene 46 protein; ACTa2 small molecule

• Purity/Purification: > 90%
• Form/Format: Freeze-Dried Powder; PBS, pH7.4, Containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Sequence Positions: Glu3~Cys11(10Val~Tyr)
• Sequence Length: 377

• Applicable Applications for ACTa2 small molecule: Immunogen, SDS-PAGE, Western Blot (WB)
• Species: Human
• Tag: N-terminal His-Tag
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Subcellular Location: Cytoskeleton
• Reconstitution: Reconstitute in PBS or others.
• Preparation and Storage: Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Avoid repeated freeze/thaw cycles.; The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Product Categories/Family for ACTa2 small molecule

Developmental science; Bone metabolism

NCBI and Uniprot Product Information

• NCBI GI #: 119570540
• NCBI GeneID: 59
• UniProt Accession #: P62736
• NCBI Official Full Name: actin, alpha 2, smooth muscle, aorta, isoform CRA_a
• NCBI Official Synonym Full Names: actin alpha 2, smooth muscle
• NCBI Official Symbol: ACTA2
• NCBI Official Synonym Symbols: ACTSA
• NCBI Protein Information: actin, aortic smooth muscle
• UniProt Protein Name: Actin, aortic smooth muscle
• Protein Family: Actin
• UniProt Gene Name: ACTA2
• UniProt Synonym Gene Names: ACTSA; ACTVS
• UniProt Entry Name: ACTA_HUMAN

NCBI Description

This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a smooth muscle actin that is involved in vascular contractility and blood pressure homeostasis. Mutations in this gene cause a variety of vascular diseases, such as thoracic aortic disease, coronary artery disease, stroke, and Moyamoya disease, as well as multisystemic smooth muscle dysfunction syndrome. [provided by RefSeq, Sep 2017]

Uniprot Description

ACTA2: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Up-regulated in response to enterovirus 71 (EV71) infection. Belongs to the actin family.

Protein type: Contractile; Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 10q23.3

Cellular Component: extracellular space; smooth muscle contractile fiber; protein complex; cytoplasm; cytosol; actin cytoskeleton

Molecular Function: protein kinase binding; ATP binding

Biological Process: muscle contraction; regulation of blood pressure; response to virus; vascular smooth muscle contraction

Disease: Moyamoya Disease 5; Multisystemic Smooth Muscle Dysfunction Syndrome; Aortic Aneurysm, Familial Thoracic 6