Human Mothers against decapentaplegic homolog 4 ELISA Kit | SMAD4 elisa kit

Human Mothers against decapentaplegic homolog 4 ELISA Kit

Reactivity

Human

Synonyms

Mothers against decapentaplegic homolog 4; Human Mothers against decapentaplegic homolog 4 ELISA Kit; MAD homolog 4; Mothers against DPP homolog 4; Deletion target in pancreatic carcinoma 4; SMAD family member 4; SMAD 4; Smad4; hSMAD4; SMAD4 elisa kit

Ordering
Cat. Num. AAA9427921 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Reactivity

Human

Samples

Serum, plasma, tissue homogenates and other biological fluids.

Detection Range

15.6-1000 pg/mL

Assay Time

3-5h

Sample Volume

100T

Detection Wavelength

450 nm

Preparation and Storage

Store at 4 degree C

NCBI and Uniprot Product Information

NCBI GI #

4885457

NCBI GeneID

4089

NCBI Accession #

NP_005350.1

NCBI GenBank Nucleotide #

NM_005359.5

UniProt Accession #

Q13485; A8K405

Molecular Weight

60,439 Da

NCBI Official Full Name

mothers against decapentaplegic homolog 4

UniProt Protein Name

Mothers against decapentaplegic homolog 4

Protein Family

Mothers against decapentaplegic

UniProt Gene Name

SMAD4

UniProt Synonym Gene Names

DPC4; MADH4; MAD homolog 4; Mothers against DPP homolog 4; SMAD 4; Smad4; hSMAD4

Uniprot Description

SMAD4: transcription factor that mediates signal transduction by the transforming growth factor superfamily. The common smad (co-smad). Binds directly to consensus DNA-binding elements in the promoters of target genes. Promotes binding of the Smad2/Smad4/Fast-1 complex to DNA and provides an activation function required for Smad1 or Smad2 to stimulate transcription.

Protein type: DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 18q21.2

Cellular Component: centrosome; cytoplasm; cytosol; nuclear chromatin; nucleoplasm; nucleus; transcription factor complex

Molecular Function: DNA binding; identical protein binding; protein binding; protein homodimerization activity; sequence-specific DNA binding; sulfate binding; transcription factor activity; transforming growth factor beta receptor, common-partner cytoplasmic mediator activity

Biological Process: BMP signaling pathway; cellular iron ion homeostasis; negative regulation of cell growth; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; palate development; positive regulation of BMP signaling pathway; positive regulation of histone H3-K4 methylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; protein deubiquitination; regulation of transforming growth factor beta receptor signaling pathway; regulation of transforming growth factor-beta2 production; response to hypoxia; SMAD protein complex assembly; somatic stem cell maintenance; transforming growth factor beta receptor signaling pathway

Disease: Juvenile Polyposis Syndrome; Juvenile Polyposis/hereditary Hemorrhagic Telangiectasia Syndrome; Myhre Syndrome; Pancreatic Cancer

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Product Notes

The Human SMAD4 smad4 (Catalog #AAA9427921) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9427921 ELISA Kit recognizes Human SMAD4. It is sometimes possible for the material contained within the vial of "Mothers against decapentaplegic homolog 4, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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Human Mothers against decapentaplegic homolog 4 ELISA Kit | SMAD4 elisa kit