NHEDC2 Blocking Peptide | SLC9B2 blocking peptide

NHEDC2 Antibody (C-term) Blocking Peptide

• Gene Names: SLC9B2; NHA2; NHE10; NHEDC2
• Synonyms: NHEDC2; NHEDC2 Antibody (C-term) Blocking Peptide; Mitochondrial sodium/hydrogen exchanger 9B2; Mitochondrial Na(+)/H(+) exchanger NHA2; Na(+)/H(+) exchanger-like domain-containing protein 2; NHE domain-containing protein 2; Sodium/hydrogen exchanger-like domain-containing protein 2; Solute carrier family 9 subfamily B member 2; SLC9B2; NHA2; SLC9B2 blocking peptide

• Form/Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
• Sequence Length: 537

• Function: Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane (PubMed:18000046, PubMed:28154142, PubMed:22948142, PubMed:18508966). Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity). Involved in sperm motility and fertility (By similarity). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity).
• Cellular Location: Cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Endosome membrane {ECO:0000250|UniProtKB:Q5BKR2}; Multi- pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q5BKR2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5BKR2}. Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:Q5BKR2}; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250|UniProtKB:Q5BKR2}; Multi-pass membrane protein. Apical cell membrane {ECO:0000250|UniProtKB:Q5BKR2}; Multi-pass membrane protein. Note=Strong colocalization with LAMP1 and TCIRG1 in osteoclasts. In beta-cells colocalizes with RAB4A and SYP. Localizes to the basolateral membrane of polarized osteoclasts. {ECO:0000250|UniProtKB:Q5BKR2}
• Tissue Location: Widely expressed (PubMed:18508966). High levels detected in the distal tubules of the kidney nephron (PubMed:18508966) Detected in red blood cells (at protein level) (PubMed:18000046, PubMed:18508966).
• Preparation and Storage: Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.

Related Product Information for SLC9B2 blocking peptide

Sodium hydrogen antiporters, such as NHEDC2, convert theproton motive force established by the respiratory chain or theF1F0 mitochondrial ATPase into sodium gradients that drive otherenergy-requiring processes, transduce environmental signals intocell responses, or function in drug efflux (Xiang etal., 2007[PubMed 18000046]).

NCBI and Uniprot Product Information

• NCBI GI #: 121944426
• NCBI GeneID: 133308
• UniProt Accession #: Q86UD5; Q6ZMD8; Q96D95; B5ME52
• NCBI Official Full Name: Mitochondrial sodium/hydrogen exchanger 9B2
• NCBI Official Synonym Full Names: solute carrier family 9 member B2
• NCBI Official Symbol: SLC9B2
• NCBI Official Synonym Symbols: NHA2; NHE10; NHEDC2
• NCBI Protein Information: mitochondrial sodium/hydrogen exchanger 9B2
• UniProt Protein Name: Mitochondrial sodium/hydrogen exchanger 9B2
• Protein Family: Mitochondrial sodium/hydrogen exchanger
• UniProt Gene Name: SLC9B2
• UniProt Synonym Gene Names: NHA2; NHEDC2; NHE domain-containing protein 2
• UniProt Entry Name: SL9B2_HUMAN

NCBI Description

Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 [PubMed 18000046]).[supplied by OMIM, Mar 2008]

Uniprot Description

NHEDC2: Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, ion channel; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: mitochondrial inner membrane

Molecular Function: monovalent cation:proton antiporter activity