Human Sodium-dependent serotonin transporter ELISA Kit | SLC6A4 elisa kit

Human Sodium-dependent serotonin transporter ELISA Kit

Cat. Num. AAA2881658

• Gene Names: SLC6A4; HTT; 5HTT; OCD1; SERT; 5-HTT; SERT1; hSERT; 5-HTTLPR
• Reactivity: Human
• Synonyms: Sodium-dependent serotonin transporter; Human Sodium-dependent serotonin transporter ELISA Kit; 5HT transporter; 5HTT; Solute carrier family 6 member 4; SLC6A4; HTT; SERT; SLC6A4 elisa kit

• Reactivity: Human
• Sequence Length: 630

• Assay Type: Sandwich
• Detection Range: 31.2-2000 pg/mL
• Sensitivity: 7.9pg/ml
• Intra-Assay CV: <=4.3%
• Inter-Assay CV: <=8.2%
• Recovery: 105%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 4507043
• NCBI GeneID: 6532
• NCBI Accession #: NP_001036.1
• NCBI GenBank Nucleotide #: NM_001045.5
• UniProt Accession #: P31645; Q5EE02; AAB26687
• Molecular Weight: 74,979 Da
• NCBI Official Full Name: sodium-dependent serotonin transporter
• NCBI Official Synonym Full Names: solute carrier family 6 (neurotransmitter transporter), member 4
• NCBI Official Symbol: SLC6A4
• NCBI Official Synonym Symbols: HTT; 5HTT; OCD1; SERT; 5-HTT; SERT1; hSERT; 5-HTTLPR
• NCBI Protein Information: sodium-dependent serotonin transporter
• UniProt Protein Name: Sodium-dependent serotonin transporter
• Protein Family: Sodium-dependent serotonin transporter
• UniProt Gene Name: SLC6A4
• UniProt Synonym Gene Names: HTT; SERT; 5HTT
• UniProt Entry Name: SC6A4_HUMAN

NCBI Description

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]

Uniprot Description

SERT: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: cytosol; endomembrane system; endosome membrane; integral to plasma membrane; lipid raft; neuron projection; plasma membrane

Molecular Function: actin filament binding; cocaine binding; monoamine transmembrane transporter activity; myosin binding; nitric-oxide synthase binding; protein binding; protein homodimerization activity; Rab GTPase binding; serotonin transmembrane transporter activity; serotonin:sodium symporter activity; syntaxin-1 binding

Biological Process: brain morphogenesis; circadian rhythm; memory; monoamine transport; negative regulation of granule cell precursor proliferation; negative regulation of neuron differentiation; negative regulation of organ growth; negative regulation of synaptic transmission, dopaminergic; positive regulation of cell cycle; protein homooligomerization; protein oligomerization; response to drug; response to estradiol stimulus; response to hypoxia; response to nutrient; response to toxin; serotonin transport; serotonin uptake; social behavior; sperm ejaculation; synaptic transmission; thalamus development; transmembrane transport; vasoconstriction

Disease: Anxiety; Obsessive-compulsive Disorder