Mouse solute carrier family 4, sodium borate transporter, member 11 ELISA Kit | SLC4A11 elisa kit
Mouse Sodium bicarbonate transporter-like protein 11, SLC4A11 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SLC4A11: Transporter which plays an important role in sodium- mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration. Involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter. Defects in SLC4A11 are the cause of corneal dystrophy and perceptive deafness (CDPD); also known as corneal dystrophy and sensorineural deafness or Harboyan syndrome. CDPD consists of congenital corneal endothelial dystrophy and progressive perceptive deafness. Inheritance is autosomal recessive. Defects in SLC4A11 are the cause of corneal endothelial dystrophy type 2 (CHED2); also known as congenital hereditary endothelial dystrophy of cornea. This bilateral corneal dystrophy is characterized by corneal opacification and nystagmus. Inheritance is autosomal recessive. Defects in SLC4A11 are the cause of corneal dystrophy Fuchs endothelial type 4 (FECD4); also known as Corneal dystrophy Fuchs endothelial late-onset. It is an ocular disorder caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition. Belongs to the anion exchanger (TC 2.A.31) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: membrane; integral to plasma membrane; cell; plasma membrane; integral to membrane
Molecular Function: protein dimerization activity; bicarbonate transmembrane transporter activity; transporter activity; inorganic anion exchanger activity; anion:anion antiporter activity; symporter activity; boron transporter activity; anion transmembrane transporter activity; hydrogen ion channel activity; sodium channel activity
Biological Process: proton transport; cellular cation homeostasis; fluid transport; transport; ion homeostasis; inorganic anion transport; bicarbonate transport; sodium ion transport; regulation of intracellular pH; ion transport; anion transport; boron transport
Research Articles on SLC4A11
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Product Notes
The Mouse SLC4A11 slc4a11 (Catalog #AAA9334886) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9334886 ELISA Kit recognizes Mouse SLC4A11. It is sometimes possible for the material contained within the vial of "solute carrier family 4, sodium borate transporter, member 11, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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