Human solute carrier family 39 (zinc transporter) , member 4 ELISA Kit | SLC39A4 elisa kit
Human Zinc transporter ZIP4, SLC39A4 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Uniprot Description
SLC39A4: Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability. Defects in SLC39A4 are the cause of acrodermatitis enteropathica zinc-deficiency type (AEZ). AEZ is a rare autosomal recessive disease caused by the inability to absorb sufficient zinc. The clinical features are growth retardation, immune system dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. All these manifestations are reversible with zinc supplementation. Without zinc therapy this disease is fatal. Belongs to the ZIP transporter (TC 2.A.5) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: recycling endosome membrane; cytoplasmic membrane-bound vesicle; apical plasma membrane; integral to membrane; plasma membrane
Molecular Function: zinc ion transmembrane transporter activity
Biological Process: cellular zinc ion homeostasis; transmembrane transport
Disease: Acrodermatitis Enteropathica, Zinc-deficiency Type
Research Articles on SLC39A4
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Product Notes
The Human SLC39A4 slc39a4 (Catalog #AAA9322330) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9322330 ELISA Kit recognizes Human SLC39A4. It is sometimes possible for the material contained within the vial of "solute carrier family 39 (zinc transporter) , member 4, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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