Rat solute carrier family 34 (sodium phosphate) , member 2 ELISA Kit | SLC34A2 elisa kit
Rat Sodium-dependent phosphate transport protein 2B, SLC34A2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
may act as a sodium dependent phosphate transporter; may provide inorganic phosphate for the synthesis of lung surfactant [RGD, Feb 2006]
Uniprot Description
SLC34A2: May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli. Defects in SLC34A2 are a cause of pulmonary alveolar microlithiasis (PALM). Pulmonary alveolar microlithiasis is a rare disease characterized by the deposition of calcium phosphate microliths throughout the lungs. Most patients are asymptomatic for several years or even for decades and generally, the diagnosis is incidental to clinical investigations unrelated to the disease. Cases with early onset or rapid progression are rare. A 'sandstorm-appearing' chest roentgenogram is a typical diagnostic finding. The onset of this potentially lethal disease varies from the neonatal period to old age and the disease follows a long-term, progressive course, resulting in a slow deterioration of lung functions. Pulmonary alveolar microlithiasis is a recessive monogenic disease with full penetrance. A chromosomal aberration involving SLC34A2 is found in a non-small cell lung cancer cell line. Results in the formation of a SLC34A2-ROS1 chimeric protein that retains a constitutive kinase activity. Belongs to the SLC34A transporter family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter; Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral
Cellular Component: brush border membrane; microvillus membrane; apical plasma membrane; integral to membrane; brush border; vesicle
Molecular Function: protein domain specific binding; sodium ion binding; phosphate binding; sodium-dependent phosphate transmembrane transporter activity; sodium:phosphate symporter activity
Biological Process: cellular phosphate ion homeostasis; phosphate transport; response to estrogen stimulus; in utero embryonic development; response to fructose stimulus; response to estradiol stimulus; aging
Research Articles on SLC34A2
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Product Notes
The Rat SLC34A2 slc34a2 (Catalog #AAA9326581) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9326581 ELISA Kit recognizes Rat SLC34A2. It is sometimes possible for the material contained within the vial of "solute carrier family 34 (sodium phosphate) , member 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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